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Research Article

IL1R2多态性与食管癌风险增加相关

卷 20, 期 5, 2020

页: [379 - 387] 页: 9

弟呕挨: 10.2174/1566524019666191025091204

价格: $65

摘要

背景：食道癌（EC）是全球癌症死亡的第六大主要原因，总发病率正在上升。 目的：本研究旨在评估IL1R2单核苷酸多态性与中国人群EC风险之间的关系。 方法：使用Agena MassARRAY平台从384 EC和499对照中对IL1R2的6个SNP进行基因分型。多态性和EC风险之间的关联通过执行遗传模型和单元型分析进行评估。 结果：总体分析结果显示，rs11674595的等位基因C（比值[OR] = 1.42，95％置信区间[CI]：1.14-1.77，p = 0.002）和rs2072472的等位基因G（等位基因：OR = 1.35，95） ％CI：1.08-1.69，p = 0.008）与EC风险增加相关。在共显性，显性和加性模型下，发现rs11674595和rs2072472与EC风险相关。分层分析发现，rs11674595和rs2072472与男性和年龄大于55岁的亚组的EC风险增加相关。此外，Crs11674595Grs4851527单倍型与EC风险增加1.44倍显着相关（95％CI：1.12-1.84，p = 0.004）。 结论：我们的结果揭示了中国汉族人群IL1R2中SNPs（rs11674595和rs2072472）与EC风险之间的显着相关性。这些发现可能为预防和治疗乳糜泻提供有意义的参考。

关键词: 食管癌，IL1R2，多态性，病例对照研究，SNP，肿瘤发生。

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