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Review Article

miRNA替代疗法在肝细胞癌中的前景

卷 19, 期 5, 2019

页: [290 - 304] 页: 15

弟呕挨: 10.2174/1566523219666191023101433

价格: $65

摘要

肝细胞癌是一种毁灭性肿瘤，占全球死亡率的94％，每年约有780,000例新病例。 肿瘤抑制miRNA代表一类非编码RNA，在致癌作用下其表达降低或受到抑制。 因此，这些分子的替换导致数十至数百个致癌靶标的转录后调节并限制了肿瘤。 有趣的是，在HCC中已经突出显示了一组肿瘤沉默基因miRNA，在本文中，我们的综述将讨论这些miR的突出实例，包括使用载体，纳米递送系统，其体外或体外成功模型的有效递送。 体内和临床前试验。 总的来说，抑癌药miRNA可以作为HCC的新型疗法，因此，更多的研究应针对这些有前途的疗法。

关键词: RNA治疗，肿瘤抑制miRNA，纳米递送，肝细胞癌，慢性感染，基因治疗。

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图形摘要

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