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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

去甲去氢愈创木酸在治疗中的应用：有利于毒性谱及其类似物的搜索

卷 20, 期 2, 2020

页: [86 - 103] 页: 18

弟呕挨: 10.2174/1568009619666191022141547

价格: $65

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摘要

去甲双氢愈创木酸（NDGA）是一种植物木脂素，得自杂草丛生的Larrea tridentata，具有抗氧化，抗癌活性，在北美和墨西哥被用于传统医学。但是，长时间食用会导致肝损伤和肾功能不全。尽管其毒性和副作用，但几乎没有意识来禁止它的消费，并且多年来一直在治疗医学疾病中使用它。迄今为止，有几篇报道讨论了其治疗效率，其医学应用正在极大地兴起。最近对于用于治疗应用的NDGA衍生物的化学合成产生了兴趣。 NDGA衍生物已被开发为NDGA的更好替代品。尽管如最近的文献所证明，已经化学合成了几种NDGA衍生物，但是关于其治疗功效的信息很少。这篇综述旨在突出NDGA的医学应用，其毒性评估，并讨论迄今为止合成和研究的NDGA的化学衍生物，并建议在开发用于治疗用途的NDGA类似物方面继续进行研究。我们建议对NDGA衍生物进行化学合成方面的研究，以其优选的构象结构进行研究，并利用其生物学潜能与未来的见识，探索这一方向，以设计和开发具有潜在药理特性的结构修饰的NDGA衍生物。

关键词: 抗癌活性，抗氧化活性，抗病毒活性，去甲二氢愈创木酸，合成类似物，毒性。

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图形摘要

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