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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

三氧化二砷抗癌模式的新颖机理研究

卷 20, 期 2, 2020

页: [115 - 129] 页: 15

弟呕挨: 10.2174/1568009619666191021122006

价格: $65

摘要

砷是一种天然存在的有毒元素，也是一种传统使用的药物，由于其在急性早幼粒细胞白血病患者中具有治愈性的抗癌特性，因此受到了全世界的广泛关注。在砷剂中，三氧化二砷已被最广泛地用作抗癌药。癌症治疗学的最新进展已导致范式从传统的细胞毒性药物转向靶向与驱动癌症表型密切相关的蛋白质。由于ATO对不同类型的恶性肿瘤具有不同的抗癌作用，因此许多研究努力揭示了ATO诱导的肿瘤抑制机制。从体外细胞模型到临床研究，ATO已得到广泛研究。这些研究的结果为建立用于癌症治疗的分子靶向疗法提供了方便。通过与其他药物联合使用，ATO的功效得以增强。在这篇综述中，我们讨论了最近基于砷的癌症疗法，并总结了ATO抗癌作用的新型潜在分子机制。

关键词: 砷，抗癌药，化学疗法，细胞凋亡，活性氧，急性早幼粒细胞白血病。

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图形摘要

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