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General Review Article

调节性T细胞在癌症免疫治疗中的分子标记，特别关注急性髓系白血病(AML) -系统综述

卷 27, 期 28, 2020

页: [4673 - 4698] 页: 26

弟呕挨: 10.2174/0929867326666191004164041

价格: $65

摘要

只有深入了解Treg细胞在抗肿瘤免疫中的作用和调节，并发现新的免疫靶点，新一代免疫治疗才能有效。这可以提高未来和新疗法的临床疗效，并减少由后者引起的不良反应。本文讨论了在肿瘤微环境(TME)中使用调节性T (Treg)细胞治疗肿瘤的策略。讨论了影响TME不稳定的因素以及预防未来免疫紊乱的相关治疗方法。据预测，PD-1抑制剂有风险，在治疗急性髓系白血病(AML)、肺腺癌和前列腺腺癌时应考虑其不良反应。相比之下，本文分析的Treg分子标记FoxP3和CD25在几乎所有癌症中都比正常人表达更强。然而，与FoxP3抑制剂相比，CD25抑制剂在预测患者生存方面更有效，尤其是在联合TGF-β阻滞剂时。根据癌症基因组图谱获得的数据，我们聚焦AML免疫治疗，讨论不同的治疗策略，包括抗CD25/IL-2、抗CTLA-4、抗IDO、抗酪氨酸激酶受体、抗PI3K治疗，并重点介绍AML免疫治疗的最新进展和临床成果。为了预测关键靶标抑制剂(即CTLA-4、FoxP3、CD25和PD-1)的风险和副作用，我们最终分析并比较了来自10种常见癌症的癌症基因组图谱。本综述显示Treg细胞在AML中显著增加，关键标志物的比较综述表明，Treg免疫治疗并不是对所有类型的癌症都有效。因此，AML中阻滞CD25(+)FoxP3(+) Treg细胞的提示多于其他类型的癌症;同时，在其他癌症中研究的Treg标记也为AML免疫治疗提供了很好的借鉴。

关键词: 调节性T细胞，肿瘤微环境，癌症免疫治疗，CD25

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