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Review Article

阿尔茨海默氏病和胃肠道微生物群之间的分子联系：强调幽门螺杆菌感染的参与。

卷 20, 期 1, 2020

页: [3 - 12] 页: 10

弟呕挨: 10.2174/1566524019666190917125917

价格: $65

摘要

阿尔茨海默氏病（AD）是一种神经退行性疾病，是痴呆症的主要形式，其特征是在个人家庭和全球范围内，进行性认知能力下降和有害后果。 在本篇叙事综述中，我们提供了Tau（与微管AD相关的蛋白）以及淀粉样蛋白β的最新分子方面，它们参与了AD病理生理。 此外，我们提供了来自基础研究和临床研究的其他新兴数据，这些数据表明胃肠道菌群（GI-M），包括幽门螺杆菌感染（Hp-I）在AD病理生理学中具有重要作用。 同样，我们通过分子棱镜确定了AD发病机理的当前证据以及其与GI-M的联系，并强调了Hp-1的作用。 总而言之，需要进一步的大规模研究来进一步阐明AD的病理生理及其与GI-M和Hp-I的联系，从而使基于分子的新疗法成为可能。

关键词: 阿尔茨海默氏病，陶氏病，β淀粉样蛋白，胃肠道菌群，幽门螺杆菌，过度磷酸化。

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