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Review Article

Trojan微粒可用于眼科药物输送

卷 27, 期 4, 2020

页: [570 - 582] 页: 13

弟呕挨: 10.2174/0929867326666190905150331

价格: $65

摘要

在二十一世纪，药物治疗眼疾仍然是一项技术挑战。尽管有重要的活性分子库可用于治疗眼病，从经典化合物到生物技术产品，但目前，尚无理想的递送系统能够发挥其全部治疗潜力。为了克服一些最重要的局限性而提出的眼内给药系统（IODDS）中，微系统和纳米系统引起了高度关注。虽然微系统能够在玻璃体内注射后提供长期释放，但纳米系统可以保护活性化合物免受外部环境的影响（减少其清除率）并将其引导至目标组织。近年来，一些研究人员探索了在“纳米微粒中的微粒（NiMs）”系统或“特洛伊木马系统”中组合微米和纳米系统的可能性。这个绝妙的主意不能免除技术问题，尤其是在IODDS的情况下，仍然是部分尚未解决的想法。本综述的目的是展示有关用于药物输送的木马微粒的设计，制备和表征的最新技术，并指出其作为IODDS的潜力和局限性，这是当前制药技术面临的最重要挑战之一。

关键词: 木马系统，纳米微粒（MiMs），眼科药物输送，后段，玻璃体内注射，眼内药物输送系统（IODDS）。

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