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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Systematic Review Article

A Systematic Review on Synthetic Drugs and Phytopharmaceuticals Used to Manage Diabetes

Author(s): Mayukh Banerjee, Rubiya Khursheed, Ankit Kumar Yadav, Sachin Kumar Singh*, Monica Gulati, Devendra Kumar Pandey, Pranav Kumar Prabhakar, Rajesh Kumar, Omji Porwal, Ankit Awasthi, Yogita Kumari, Gurmandeep Kaur, Clarisse Ayinkamiye, Rahul Prashar, Diksha Mankotia and Narendra Kumar Pandey

Volume 16, Issue 4, 2020

Page: [340 - 356] Pages: 17

DOI: 10.2174/1573399815666190822165141

Price: $65

Abstract

Background: Diabetes is a multifactorial disease and a major cause for many microvascular and macrovascular complications. The disease will ultimately lead to high rate mortality if it is not managed properly. Treatment of diabetes without any side effects has always remained a major challenge for health care practitioners.

Introduction: The current review discusses the various conventional drugs, herbal drugs, combination therapy and the use of nutraceuticals for the effective management of diabetes mellitus. The biotechnological aspects of various antidiabetic drugs are also discussed.

Methods: Structured search of bibliographic databases for previously published peer-reviewed research papers was explored and data was sorted in terms of various approaches that are used for the treatment of diabetes.

Results: More than 170 papers including both research and review articles, were included in this review in order to produce a comprehensive and easily understandable article. A series of herbal and synthetic drugs have been discussed along with their current status of treatment in terms of dose, mechanism of action and possible side effects. The article also focuses on combination therapies containing synthetic as well as herbal drugs to treat the disease. The role of pre and probiotics in the management of diabetes is also highlighted.

Conclusion: Oral antihyperglycemics which are used to treat diabetes can cause many adverse effects and if given in combination, can lead to drug-drug interactions. The combination of various phytochemicals with synthetic drugs can overcome the challenge faced by the synthetic drug treatment. Herbal and nutraceuticals therapy and the use of probiotics and prebiotics are a more holistic therapy due to their natural origin and traditional use.

Keywords: Diabetes, combination therapy, probiotics, herbal drugs, synthetic drugs, phytopharmaceuticals.

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