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Review Article

针对癌症干细胞通路，有效治疗癌症

卷 21, 期 3, 2020

页: [258 - 278] 页: 21

弟呕挨: 10.2174/1389450120666190821160730

价格: $65

摘要

化疗耐药性和复发是有效治疗癌症的主要障碍。其主要原因是肿瘤干细胞(CSCs)及其微环境的小亚群。CSCs是多种癌症的关键驱动力，如胃癌、结肠癌、乳腺癌等。因此，为了彻底根除癌症，有必要开发针对CSCs的治疗方法。针对CSC信号通路中不同蛋白的化学制剂，无论是作为单一制剂还是同时针对两种或两种以上的蛋白，都产生了有希望的临床前和临床结果。在当前的这篇综述文章中，我们讨论了可以有效彻底根除CSCs的各种靶点和细胞通路。本文综述了近年来肿瘤干细胞配体的设计、合成和筛选方面的最新研究进展。

关键词: 肿瘤干细胞，PI3K/AKT通路，Wnt通路，hedgehog信号通路，notch信号途径，核factor-kappa-B

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