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Research Article

血清脂联素水平的降低和8-OHdG的增加：2型糖尿病老年患者认知障碍的罪魁祸首

卷 20, 期 1, 2020

页: [44 - 50] 页: 7

弟呕挨: 10.2174/1566524019666190819160403

价格: $65

摘要

背景：脂联素和8-Hydroxy-2''-deoxyguanosine（8-OHdG）被认为是2型糖尿病（T2DM）发病过程中的重要生物标志物。脂联素和8-OHdG是否与老年T2DM患者的认知能力下降有关，人们对此知之甚少。这项研究的目的是评估脂联素和8-OHdG在老年T2DM患者中的作用，并确定脂联素和8-OHdG在老年T2DM患者认知障碍中的作用。 方法：招募和分析57例个体，其中26例无认知障碍的T2DM和31例有认知障碍的T2DM。他们都在不同的时间接受了糖尿病和血糖的检查。糖尿病的初步诊断符合美国糖尿病协会（ADA）设定的诊断标准。统计显着性定义为P值小于0.05。 结果：根据探索每个变量的单因素分析，在无认知障碍和认知障碍的T2DM患者中，性别，年龄，体重指数（BMI），高血压，糖尿病，代谢综合征，腔隙性脑梗塞，吸烟和饮酒等变量均无差异。分别变量（p> 0.05）。血清脂联素和8-OHdG的水平以及MMSE和MoCA的量表存在显着差异（p <0.05）。因此，推断T2DM患者的葡萄糖代谢值与认知结果之间没有相关性。血清脂联素和8-OHdG水平可作为老年T2DM患者认知障碍程度的生物标志物。 结论：血清脂联素和8-OHdG水平可作为特异和敏感的生物标志物，对老年T2DM患者的认知障碍进行早期诊断和治疗。血清脂联素和8-OHdG水平与老年T2DM患者的神经认知结果密切相关。

关键词: 糖尿病，脂联素，8-OhdG，认知障碍，氧化应激，T2DM。

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