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General Review Article

植物化学介导的胶质瘤靶向治疗：耐药性和新型给药系统

卷 27, 期 4, 2020

页: [599 - 629] 页: 31

弟呕挨: 10.2174/0929867326666190809221332

价格: $65

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摘要

胶质瘤，特别是其最恶性的胶质母细胞瘤（GBM），是中枢神经系统中最常见，最具侵袭性的恶性肿瘤。目前，我们尚无能显着改善其不良预后的特异性疗法。最近的研究报道了几种靶向神经胶质瘤的新型药物的有希望的体外实验结果。这些研究对研究人员和患者都鼓舞。但是，临床试验表明，仅关注单一的，明确的神经胶质瘤基因改变的新型化合物可能无法获得令人满意的结果或产生难以忍受的副作用。基于该共识，具有多种生物活性的植物化学物质最近引起了广泛关注。中药和印度传统药（阿育吠陀）显示，植物化合物抑制神经胶质瘤的血管生成，癌干细胞和肿瘤的增殖。这些结果表明了一种新颖的药物治疗策略。但是，单一的植物化合物或其直接使用可能不会逆转综合性恶性肿瘤，因为其组织学穿透性差或体内效率相对不令人满意。近期使用替莫唑胺联合治疗以及纳米颗粒（NPs）与植物化合物的研究表明，该药物具有强大的双重靶标疗法和较高的血脑屏障穿透性，且副作用低且靶向性强。这篇综述的重点是近年来对胶质瘤靶向治疗做出贡献的主要植物化合物及其在耐药性抑制中的作用，以及针对临床策略的新型药物递送系统。最后，我们总结了未来可能的研究策略。

关键词: 植物化学，神经胶质瘤，成胶质细胞瘤，耐药性，药物递送系统，纳米颗粒。

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