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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Meta-Analysis

PICALM基因多态性与阿尔茨海默病的关系：最新Meta分析的证据

卷 16, 期 13, 2019

页: [1196 - 1205] 页: 10

弟呕挨: 10.2174/1567205016666190805165607

价格: $65

摘要

背景：先前的研究检查了PICALM基因的三个多态性（rs3851179，rs541458和rs592297）在阿尔茨海默氏病（AD）易感性中的作用，但尚无定论。 目的：我们进行了Meta分析，以探讨PICALM基因中的这三个多态性是否与AD易感性相关。 方法：在PubMed，Embase，Web of Science和中国国家知识基础设施（CNKI）数据库中进行书目搜索。摘要概率比（OR）和95％置信区间（CI）用于评估随机效应模型中关联的强度。通过亚组和Meta回归分析确定了异质性的潜在来源。 结果：rs3851179的20项研究（9,017例和15,448例对照），rs541458的12项研究（8,077例和12022例对照）以及rs592297的4项研究（2,106例和2,234例对照）被认为符合Meta分析标准。对于rs3851179和rs541458而言，在具有轻度异质性的所有遗传模型下，总体OR均显着。与G携带者相比，rs3851179的A携带者与AD风险降低相关（OR = 0.88; 95％CI 0.84，0.91，Z检验的P <0.001，I2 = 0.0％）。与T携带者相比，rs541458的C携带者与AD风险呈负相关（OR = 0.86； 95％CI 0.81、0.92，Z检验的P <0.001，I2 = 39.5％）。 rs592297未发现关联。亚组和Meta回归分析表明，rs541458 C等位基因的保护作用仅在白种人中观察到，而在亚洲人中则没有观察到（相互作用P：0.021〜<0.001）。 结论：rs3851179和rs541458似乎与AD风险降低有关。 rs592297与AD风险的无效关联需要与更多的参与者进一步确认。

关键词: 阿尔茨海默氏病，单核苷酸多态性，PICALM基因，Meta分析，流行病学，优势比。

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