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Review Article

用中药靶向蛋白激酶抑制剂

卷 20, 期 15, 2019

页: [1505 - 1516] 页: 12

弟呕挨: 10.2174/1389450120666190802125959

价格: $65

摘要

蛋白激酶通过其催化活性在控制细胞生长，增殖，迁移和血管生成中起关键作用。在过去的几年中，已经发现了许多蛋白激酶抑制剂，并已在临床上成功使用。中药（TCM）代表了一大类生物活性物质，其中一些通过抑制蛋白激酶信号通路表现出抗癌活性。在中国，一些中医已被用于临床治疗肿瘤多年。 p38丝裂原活化蛋白激酶（MAPK），磷酸肌醇3激酶，丝氨酸/苏氨酸特异性蛋白激酶（PI3K / AKT / mTOR）和细胞外信号调节激酶（ERK）途径被认为是癌细胞发展中的重要信号。在本文中，讨论了对多种蛋白激酶具有显着抑制活性的中药的最新进展。还提出了对蛋白激酶具有抑制作用的中药在治疗肿瘤中的临床疗效。本文还讨论了中药开发抗癌药物的前景和问题。

关键词: 中药，蛋白激酶抑制剂，抗癌活性，PI3K / AKT / mTOR，MAPK，ERK。

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