Search Result "transition state isosteres"


Targeting Enzymes with Phosphonate-Based Inhibitors: Mimics of Tetrahedral Transition States and Stable Isosteric Analogues of Phosphates

Journal: Current Enzyme Inhibition
Volume: 2 Issue: 1 Year: 2006 Page: 61-72
Author(s): L. Azema, R. Baron, S. Ladame

Inhibition of BACE-1 by Hydroxyethylsulfide, Hydroxyethylamine and Hydroxyethylurea Isosteric Replacements

Journal: Letters in Drug Design & Discovery
Volume: 2 Issue: 2 Year: 2005 Page: 109-112
Author(s): L. Rizzi, S. Romeo

Design, Synthesis and Docking Studies of Hydroxyethylamine and Hydroxyethylsulfide BACE-1 Inhibitors

Journal: Protein & Peptide Letters
Volume: 16 Issue: 1 Year: 2009 Page: 86-90
Author(s): Luca Rizzi, Nadia Vaiana, Francesca Sagui, Eva Genesio, Elena Pilli, Valentina Porcari, Sergio Romeo

3,4-Dihydroxypyrrolidine as Glycosidase Inhibitor

Journal: Current Topics in Medicinal Chemistry
Volume: 9 Issue: 1 Year: 2009 Page: 34-57
Author(s): Katsuhiko Suzuki, Tatsuto Nakahara, Osamu Kanie

Computational Modeling of Coordination Chemistry of Transition Metal Cations in Zeolites and in Metal-organic Frameworks

Journal: Current Physical Chemistry
Volume: 2 Issue: 2 Year: 2012 Page: 189-199
Author(s): Hristiyan A. Aleksandrov, Petko St. Petkov, Georgi N. Vayssilov

Origin of Chiral Pharmacology Stereochemistry in Metalloprotease Inhibition

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 1 Issue: 2 Year: 2001 Page: 155-161
Author(s): D. H. Kim

Recent Advances in the Synthesis and Applications of Reduced Amide Pseudopeptides

Journal: Current Medicinal Chemistry
Volume: 16 Issue: 1 Year: 2009 Page: 2289-2304
Author(s): Matej Zivec, Ziga Jakopin, Stanislav Gobec

Recent Progress in the Medicinal Chemistry of γ-Secretase Inhibitors

Journal: Current Topics in Medicinal Chemistry
Volume: 8 Issue: 1 Year: 2008 Page: 17-33
Author(s): Richard E. Olson, Charles F. Albright

New Cathepsin D Inhibitor Library Utilizing Hydroxyethyl Isosteres with Cyclic Tertiary Amines

Journal: Medicinal Chemistry
Volume: 8 Issue: 6 Year: 2012 Page: 1146-1154
Author(s): Rose M. McConnell, Kalyani Inapudi, Naveen Kadasala, Karthika Yarlagadda, Priya Velusamy, Matthew S. McConnell, Adam Green, Carol Trana, Kelley Sayyar, James S. McConnell

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