Search Result "scaffold-hopping"


On Scaffolds and Hopping in Medicinal Chemistry

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 6 Issue: 1 Year: 2006 Page: 1217-1229
Author(s): Nathan Brown, Edgar Jacoby

Research Article

Forging New Scaffolds from Old: Combining Scaffold Hopping and Hierarchical Virtual Screening for Identifying Novel Bcl-2 Inhibitors

Journal: Current Topics in Medicinal Chemistry
Volume: 19 Issue: 13 Year: 2019 Page: 1162-1172
Author(s): Vishnupriya Kanakaveti,Sakthivel Rathinasamy,Suresh K. Rayala,Michael Gromiha

Research Article

Synthesis and Neuroprotective Biological Evaluation of Quinazolinone Derivatives via Scaffold Hopping

Journal: Current Organic Synthesis
Volume: 16 Issue: 5 Year: 2019 Page: 772-775
Author(s): Fan Yang,Wei-Ping He,Jia-Qi Yao,Dong Zou,Pu Chen,Jie Li

Initial Design and Synthesis of Conformationally Restricted and Pharmacophore-Based Scaffold Hopping Analogs of a Ras Pathway Modulator and Evaluation of Their MAPK Inhibitory Activities

Journal: Letters in Drug Design & Discovery
Volume: 3 Issue: 1 Year: 2006 Page: 44-48
Author(s): Sukumar Sakamuri, Quin-Zene Chen, Yingchun Lu, Yen-Fang Keng, Vladimir Khazak, Katrin Illgen, Silke Schabbert, Lutz Weber, Sanjay R. Menon

Scaffold-Hopping Potential of Fragment-Based De Novo Design: The Chances and Limits of Variation

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 12 Issue: 4 Year: 2009 Page: 383-396
Author(s): Bjoern A. Krueger, Axel Dietrich, Karl-Heinz Baringhaus, Gisbert Schneider

Research Article

Drug Repurposing Using Similarity-based Target Prediction, Docking Studies and Scaffold Hopping of Lefamulin

Journal: Letters in Drug Design & Discovery
Volume: 18 Issue: 7 Year: 2021 Page: 733-743
Author(s): Shikha Sharma,Shweta Sharma,Vaishali Pathak,Parwinder Kaur,Rajesh Kumar Singh

Letter Article

Design, Synthesis, Insecticidal Evaluation and Modeling Studies on 1,4,6,7- tetrahydropyrazolo[3,4-d][1,3]oxazine Derivatives: An Application of Scaffold Hopping Strategy on Fipronil

Journal: Letters in Drug Design & Discovery
Volume: 16 Issue: 10 Year: 2019 Page: 1175-1180
Author(s): Guanglong Li,Cong Zhou,Chengchun Zhu,Lujue He,Xiaoyang Li,Zhiping Xu,Xiaoyong Xu,Xusheng Shao,Zhong Li,Jiagao Cheng

Self-Organizing Maps in Drug Discovery: Compound Library Design, Scaffold-Hopping, Repurposing

Journal: Current Medicinal Chemistry
Volume: 16 Issue: 3 Year: 2009 Page: 258-266
Author(s): P. Schneider, Y. Tanrikulu, G. Schneider

Research Article

Scaffold Hopping Strategy for the Design, Synthesis and Biological Activity Evaluation of Novel Hexacyclic Scutellarein Derivatives with a 1,3-Oxazine Ring Fused at A-ring

Journal: Medicinal Chemistry
Volume: 14 Issue: 5 Year: 2018 Page: 478-484
Author(s): Yue Zhong,Yu-Ting Lu,Ying Sun,Nian-Guang Li,Ting Gu,Wen-Yu Wu,Shao-Peng Yu,Zhi-Hao Shi

Robust Modeling and Scaffold Hopping: Case Study Based on HIV Reverse Transcriptase Inhibitors Type-1 Data

Journal: Medicinal Chemistry
Volume: 12 Issue: 6 Year: 2016 Page: 513-526
Author(s):

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