Search Result "false positive hit"


False Positives in the Early Stages of Drug Discovery

Journal: Current Medicinal Chemistry
Volume: 17 Issue: 3 Year: 2010 Page: 4231-4255
Author(s): R. Sink, S. Gobec, S. Pecar, A. Zega

NMR-Based Quality Control Approach for the Identification of False Positives and False Negatives in High Throughput Screening

Journal: Current Drug Discovery Technologies
Volume: 3 Issue: 2 Year: 2006 Page: 115-124
Author(s): Claudio Dalvit, Dannica Caronni, Nicola Mongelli, Marina Veronesi, Anna Vulpetti

Enzyme Kinetics and Hit Validation in Fluorimetric Protease Assays

Journal: Current Topics in Medicinal Chemistry
Volume: 10 Issue: 3 Year: 2010 Page: 368-382
Author(s): Stephanie Ludewig, Markus Kossner, Markus Schiller, Knut Baumann, Tanja Schirmeister

Using IMAP Technology to Identify Kinase Inhibitors: Comparison with a Substrate Depletion Approach and Analysis of the Nature of False Positives

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 8 Issue: 4 Year: 2005 Page: 319-325
Author(s): P. Singh, B. Lillywhite, C. Bannaghan, P. Broad

Efficient Optimization Strategy for Marginal Hits Active Against abl Tyrosine Kinases

Journal: Current Drug Discovery Technologies
Volume: 1 Issue: 3 Year: 2004 Page: 201-210
Author(s): Sergey E. Tkachenko, Ilya Okun, Konstantin V. Balakin, Charles E. Petersen, Yan A. Ivanenkov, Nikolay P. Savchuk, Andrey A. Ivashchenko

NMR Screening and Hit Validation in Fragment Based Drug Discovery

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 1 Year: 2011 Page: 43-67
Author(s): Ramon Campos-Olivas

Lead Generation - Enhancing the Success of Drug Discovery by Investing in the Hit to Lead Process

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 6 Issue: 1 Year: 2003 Page: 51-66
Author(s): Alexander Alanine, Matthias Nettekoven, Edward Roberts, Andrew W. Thomas

Target Immobilization and NMR Screening of Fragments in Early Drug Discovery

Journal: Current Topics in Medicinal Chemistry
Volume: 9 Issue: 1 Year: 2009 Page: 1736-1745
Author(s): Gregg Siegal, Johan G. Hollander

Rational Prediction with Molecular Dynamics for Hit Identification

Journal: Current Topics in Medicinal Chemistry
Volume: 12 Issue: 18 Year: 2012 Page: 2002-2012
Author(s): Sara E. Nichols,Robert V. Swift,Rommie E. Amaro

The Identification, Characterization and Optimization of Small Molecule Probes of Cysteine Proteases: Experiences of the Penn Center for Molecular Discovery with Cathepsin B and Cathepsin L

Journal: Current Topics in Medicinal Chemistry
Volume: 9 Issue: 1 Year: 2009 Page: 1206-1216
Author(s): Donna M. Huryn, Amos B. Smith III

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