Search Result "Brain unbound volume of distribution"


Insight into Tissue Unbound Concentration: Utility in Drug Discovery and Development

Journal: Current Drug Metabolism
Volume: 14 Issue: 3 Year: 2013 Page: 324-340
Author(s): T. Thanga Mariappan,Sandhya Mandlekar,Punit Marathe

The Role of Unbound Drug in Pharmacokinetics/Pharmacodynamics and in Therapy

Journal: Current Pharmaceutical Design
Volume: 12 Issue: 8 Year: 2006 Page: 977-987
Author(s): Rosario Calvo, John C. Lukas, Monica Rodriguez, Nerea Leal, Elena Suarez

In Silico Prediction of Brain Exposure: Drug Free Fraction, Unbound Brain to Plasma Concentration Ratio and Equilibrium Half-Life

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 7 Year: 2013 Page: 813-820
Author(s): Morena Spreafico, Matthew P. Jacobson

Review Article

Phospholipid-based Immobilized Artificial Membrane (IAM) Chromatography: A Powerful Tool to Model Drug Distribution Processes

Journal: Current Pharmaceutical Design
Volume: 23 Issue: 44 Year: 2017 Page: 6784-6794
Author(s): Anna W. Sobanska,Elzbieta Brzezinska

Assays to Predict Drug Permeation Across the Blood-Brain Barrier, and Distribution to Brain

Journal: Current Drug Metabolism
Volume: 9 Issue: 9 Year: 2008 Page: 901-910
Author(s): N. J. Abbott, D. E.M. Dolman, A. K. Patabendige

Tissue Distribution and Pharmacodynamics: A Complicated Relationship

Journal: Current Drug Metabolism
Volume: 7 Issue: 1 Year: 2006 Page: 39-65
Author(s): Jiunn H. Lin

Predicting the Volume of Distribution of Drugs in Humans

Journal: Current Drug Metabolism
Volume: 9 Issue: 6 Year: 2008 Page: 574-580
Author(s): Xiaofan Sui, Jin Sun, Xin Wu, Haiyan Li, Jianfang Liu, Zhonggui He

Review Article

Molecular Modeling Approaches for the Prediction of Selected Pharmacokinetic Properties

Journal: Current Topics in Medicinal Chemistry
Volume: 18 Issue: 26 Year: 2018 Page: 2230-2238
Author(s): Emilio S. Petito,David J.R. Foster,Michael B. Ward,Matthew J. Sykes

Using PET Studies of P-gp Function to Elucidate Mechanisms Underlying the Disposition of Drugs

Journal: Current Topics in Medicinal Chemistry
Volume: 10 Issue: 1 Year: 2010 Page: 1799-1809
Author(s): Stina Syvanen, Margareta Hammarlund-Udenaes

Review Article

Current State and Future Perspectives in QSAR Models to Predict Blood- Brain Barrier Penetration in Central Nervous System Drug R&D

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 17 Issue: 3 Year: 2017 Page: 247-257
Author(s): Juan F. Morales,Sebastian Scioli Montoto,Pietro Fagiolino,Maria E. Ruiz

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