Search Result "hit triage"

Hit Triage Using Efficiency Indices after Screening of Compound Libraries in Drug Discovery

Journal: Current Topics in Medicinal Chemistry
Volume: 9 Issue: 1 Year: 2009 Page: 1718-1724
Author(s): Allen B. Reitz, Garry R. Smith, Brett A. Tounge, Charles H. Reynolds

The Identification, Characterization and Optimization of Small Molecule Probes of Cysteine Proteases: Experiences of the Penn Center for Molecular Discovery with Cathepsin B and Cathepsin L

Journal: Current Topics in Medicinal Chemistry
Volume: 9 Issue: 1 Year: 2009 Page: 1206-1216
Author(s): Donna M. Huryn, Amos B. Smith III

A Collaborative Hit-to-Lead Investigation Leveraging Medicinal Chemistry Expertise with High Throughput Library Design, Synthesis and Purification Capabilities

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 9 Issue: 2 Year: 2006 Page: 123-130
Author(s): X. Yang, D. Parker, L. Whitehead, N. S. Ryder, B. Weidmann, M. Stabile-Harris, D. Kizer, M. McKinnon, A. Smellie, D. Powers

Integration of NMR and High-Throughput Screening

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 5 Issue: 8 Year: 2002 Page: 613-621
Author(s): Philip J. Hajduk, David J. Burns

Research Article

High Throughput Screening Assay to Identify Modulators of IL-17 Expression

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 20 Issue: 9 Year: 2017 Page: 804-819
Author(s): Mohamed Boudjelal,Ana Maria Ruiz-Avendano,Gonzalo Colmenarejo,Sergio A. Senar-Sancho,Ashley Barnes,Stephen A. Harrison

Review Article

The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization

Journal: Current Medicinal Chemistry
Volume: 26 Issue: 2 Year: 2019 Page: 3838-3873
Author(s): Agostino Bruno,Gabriele Costantino,Luca Sartori,Marco Radi

Exploring Novel Target Space: A Need to Partner High Throughput Docking and Ligand-Based Similarity Searches?

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 12 Issue: 1 Year: 2009 Page: 984-999
Author(s): Kumaran Shanmugasundaram, Alan C. Rigby

Integration of Virtual and High Throughput Screening in Lead Discovery Settings

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 14 Issue: 1 Year: 2011 Page: 889-897
Author(s): Timea Polgar, Gyorgy M. Keseru

Applications of Biophysical Tools to Target-Based Discovery of Novel Antibacterial Leads

Journal: Current Drug Targets
Volume: 13 Issue: 3 Year: 2012 Page: 388-408
Author(s): Sushmita Lahiri, Steven Kazmirski, Gunther Kern, Gautam Sanyal

Fragment-Based Discovery of Inhibitors of Protein Kinase B

Journal: Current Topics in Medicinal Chemistry
Volume: 9 Issue: 1 Year: 2009 Page: 1705-1717
Author(s): Thomas G. Davies, Steven J. Woodhead, Ian Collins

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