Search Result "hit rate"

Lead Generation - Enhancing the Success of Drug Discovery by Investing in the Hit to Lead Process

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 6 Issue: 1 Year: 2003 Page: 51-66
Author(s): Alexander Alanine, Matthias Nettekoven, Edward Roberts, Andrew W. Thomas

Enzyme Kinetics and Hit Validation in Fluorimetric Protease Assays

Journal: Current Topics in Medicinal Chemistry
Volume: 10 Issue: 3 Year: 2010 Page: 368-382
Author(s): Stephanie Ludewig, Markus Kossner, Markus Schiller, Knut Baumann, Tanja Schirmeister

Efficient Optimization Strategy for Marginal Hits Active Against abl Tyrosine Kinases

Journal: Current Drug Discovery Technologies
Volume: 1 Issue: 3 Year: 2004 Page: 201-210
Author(s): Sergey E. Tkachenko, Ilya Okun, Konstantin V. Balakin, Charles E. Petersen, Yan A. Ivanenkov, Nikolay P. Savchuk, Andrey A. Ivashchenko

Proteolytic Cleavage of Notch: “HIT and RUN”

Journal: Current Molecular Medicine
Volume: 11 Issue: 4 Year: 2011 Page: 255-269
Author(s): G. van Tetering, M. Vooijs

NMR Screening and Hit Validation in Fragment Based Drug Discovery

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 1 Year: 2011 Page: 43-67
Author(s): Ramon Campos-Olivas

A Simple Method for Analyzing Actives in Random RNAi Screens: Introducing the “H Score” for Hit Nomination & Gene Prioritization

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 15 Issue: 9 Year: 2012 Page: 686-704
Author(s): Bhavneet Bhinder,Hakim Djaballah

A Collaborative Hit-to-Lead Investigation Leveraging Medicinal Chemistry Expertise with High Throughput Library Design, Synthesis and Purification Capabilities

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 9 Issue: 2 Year: 2006 Page: 123-130
Author(s): X. Yang, D. Parker, L. Whitehead, N. S. Ryder, B. Weidmann, M. Stabile-Harris, D. Kizer, M. McKinnon, A. Smellie, D. Powers

Rational Prediction with Molecular Dynamics for Hit Identification

Journal: Current Topics in Medicinal Chemistry
Volume: 12 Issue: 18 Year: 2012 Page: 2002-2012
Author(s): Sara E. Nichols,Robert V. Swift,Rommie E. Amaro

Integrity Profiling of High Throughput Screening Hits Using LC-MS and Related Techniques

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 8 Issue: 6 Year: 2005 Page: 459-466
Author(s): Edward H. Kerns, Li Di, Jim Bourassa, Jonathan Gross, Nelson Huang, Hanlan Liu, Teresa Kleintop, Lisa Nogle, Larry Mallis, Chris Petucci, Susan Petusky, Mark Tischler, Chantel Sabus, Ani Sarkahian, Mairead Young, Mei-yi Zhang, Donna Huryn, Oliver McConnell, Guy Carter

Genomes to Hits In Silico - A Country Path Today, A Highway Tomorrow: A Case Study of Chikungunya

Journal: Current Pharmaceutical Design
Volume: 19 Issue: 26 Year: 2013 Page: 4687-4700
Author(s): Anjali Soni,Khushhali M. Pandey,Pratima Ray,B. Jayaram

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