Search Result "Mechanism based inactivation (MBI)"

Prediction of Drug-Drug Interactions Arising From Mechanism-Based Inactivation: Key Input Parameters and Impact on Risk Assessment

Journal: Current Drug Metabolism
Volume: 12 Issue: 9 Year: 2011 Page: 871-890
Author(s): Simon G. Wong

Drug-Drug Interactions via Mechanism-Based Cytochrome P450 Inactivation: Points to Consider for Risk Assessment from In Vitro Data and Clinical Pharmacologic Evaluation

Journal: Current Drug Metabolism
Volume: 8 Issue: 5 Year: 2007 Page: 449-462
Author(s): Karthik Venkatakrishnan, R. Scott Obach

Integrating In Vitro Kinetic Data from Compounds Exhibiting Induction, Reversible Inhibition and Mechanism-Based Inactivation: In Vitro Study Design

Journal: Current Drug Metabolism
Volume: 5 Issue: 2 Year: 2004 Page: 141-146
Author(s): Donavon J. McConn, Zhiyang Zhao

Mechanism-Based Inactivators as Probes of Cytochrome P450 Structure and Function

Journal: Current Drug Metabolism
Volume: 2 Issue: 3 Year: 2001 Page: 215-243
Author(s): Ute M. Kent, Monica I. Jushchhyshyn, Paul F. Hollenberg

Assessment of the Inactivation Potential of Desethylamiodarone on Human CYP1A1

Journal: Drug Metabolism Letters
Volume: 4 Issue: 1 Year: 2010 Page: 9-14
Author(s): Marwa E. Elsherbiny, Ayman O.S. El-Kadi, Dion R. Brocks

Review Article

Mechanism-Based Inhibitors from Phytomedicine: Risks of Hepatotoxicity and their Potential Hepatotoxic Substructures

Journal: Current Drug Metabolism
Volume: 17 Issue: 10 Year: 2016 Page: 971-991
Author(s): Lili Wang,Xin He,Chunhuan Jin,Gregory Ondieki

Enzyme Kinetics for Clinically Relevant CYP Inhibition

Journal: Current Drug Metabolism
Volume: 6 Issue: 3 Year: 2005 Page: 241-257
Author(s): Zhi-Yi Zhang, Y. Nancy Wong

Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 382-403
Author(s): David O. Nettleton, Heidi J. Einolf

Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions

Journal: Current Drug Metabolism
Volume: 9 Issue: 5 Year: 2008 Page: 384-393
Author(s): Jiansong Yang, Mingxiang Liao, Magang Shou, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker, Amin Rostami-Hodjegan

Inactivation of CYP3A4 by Benzbromarone in Human Liver Microsomes

Journal: Drug Metabolism Letters
Volume: 10 Issue: 1 Year: 2016 Page: 16-21
Author(s): Yasuhiro Masubuchi,Shinji Kondo

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