Search Result "HERG channel"

Review Article

How to Fluorescently Label the Potassium Channel: A Case in hERG

Journal: Current Medicinal Chemistry
Volume: 27 Issue: 18 Year: 2020 Page: 3046-3054
Author(s): Xiaomeng Zhang,Beilei Wang,Zhenzhen Liu,Yubin Zhou,Lupei Du

The Interactions Between hERG Potassium Channel and Blockers

Journal: Current Topics in Medicinal Chemistry
Volume: 9 Issue: 4 Year: 2009 Page: 330-338
Author(s): Lupei Du, Minyong Li, Qidong You

Ligand Structural Aspects of hERG Channel Blockade

Journal: Current Topics in Medicinal Chemistry
Volume: 8 Issue: 1 Year: 2008 Page: 1113-1127
Author(s): Alex M. Aronov

Lead Optimization of Melanin Concentrating Hormone Receptor 1 Antagonists with low hERG Channel Activity

Journal: Current Topics in Medicinal Chemistry
Volume: 8 Issue: 1 Year: 2008 Page: 1152-1157
Author(s): Andrew S. Judd, Andrew J. Souers, Philip R. Kym

hERG (KCNH2 or Kv11.1) K+ Channels: Screening for Cardiac Arrhythmia Risk

Journal: Current Drug Metabolism
Volume: 9 Issue: 9 Year: 2008 Page: 965-970
Author(s): Mark R. Bowlby, Ravi Peri, Howard Zhang, John Dunlop

Predictive Models for hERG Channel Blockers: Ligand-Based and Structure-Based Approaches

Journal: Current Medicinal Chemistry
Volume: 14 Issue: 2 Year: 2007 Page: 3003-3026
Author(s): Khac-Minh Thai, Gerhard F. Ecker

The hERG Channel and Risk of Drug-Acquired Cardiac Arrhythmia: An Overview

Journal: Current Topics in Medicinal Chemistry
Volume: 8 Issue: 1 Year: 2008 Page: 1102-1112
Author(s): Armando A. Lagrutta, Elena S. Trepakova, Joseph J. Salata

Recent Developments in Computational Prediction of hERG Blockage

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 11 Year: 2013 Page: 1317-1326
Author(s): Sichao Wang,Youyong Li,Lei Xu,Dan Li,Tingjun Hou

A Ligand-Based Virtual Screening Approach to Identify Small Molecules as hERG Channel Activators

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 18 Issue: 3 Year: 2015 Page: 269-280
Author(s): Elisa Giacomini,Rosa Buonfiglio,Matteo Masetti,Yuhong Wang,Gea-Ny Tseng,Marinella Roberti,Maurizio Recanatini

Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation

Journal: Current Topics in Medicinal Chemistry
Volume: 16 Issue: 16 Year: 2016 Page: 1792-1818
Author(s): Robert A. Pearlstein,K. Andrew MacCannell,Gül Erdemli,Sarita Yeola,Gabriel Helmlinger,Qi-Ying Hu,Ramy Farid,William Egan,Steven Whitebread,Clayton Springer,Jeremy Beck,Hao-Ran Wang,Mateusz Maciejewski,Laszlo Urban,José S. Duca

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