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Review Article

NMR辅助抗菌肽的设计：基于肽的结构修饰和肽的功能相关性VG16KRKP

卷 27, 期 9, 2020

页: [1387 - 1404] 页: 18

弟呕挨: 10.2174/0929867326666190624090817

价格: $65

摘要

抗菌肽（AMP）在其领域内整合了结构和功能各异的各种肽，在先天免疫中起着至关重要的作用。在过去的几十年中，AMP领域出现了巨大的增长，这主要归因于所谓的抗药性“超级细菌”的产生以及与现有抗菌剂相关的局限性。由于其具有弹性的生物学特性，AMP可以很好地形成下一代治疗剂的可持续替代品。但是，与现有AMP相关的某些缺点是必须解决的主要问题。这些限制主要包括蛋白水解切割，因此生物系统内部的稳定性差，由于与微生物膜相互作用不足而导致的活性降低，以及由于不适当的递送而导致的无效。在这种情况下，天然存在的AMPs作为产生各种合成和设计的对应物的有效原型的应用，已经发展成为基于肽的治疗的新途径。这种设计方法有助于克服母体AMP的缺点，同时保留其固有的活性。在这篇综述中，我们以16个残基的登革热病毒融合蛋白衍生肽VG16KRKP为例，总结了一些基于NMR结构的基本方法和技术，这些方法和技术可帮助提高AMPs的活性。使用基于第一原理的设计技术和基于高分辨率NMR的结构表征，我们验证了VG16KRKP的不同修饰类型，突出了关键基序，从而优化了其活性。提出的方法和设计技术可以为我们的同龄人的药物开发工作提供支持。

关键词: 抗菌肽，超级细菌，de novo肽设计，NMR光谱，trNOESY，VG16KRKP。

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