Login Register Cart 0
Systematic Review Article

植物衍生天然产物的抗炎特性–系统评价

卷 26, 期 24, 2019

页: [4506 - 4536] 页: 31

弟呕挨: 10.2174/0929867325666190523123357

价格: $65

摘要

传统上，天然药物是作为植物提取物施用的，它是由分子混合物组成的。 该混合物中的单个分子物质可能会或可能不会对整体药物作用做出贡献，有些甚至会阻碍其他药物的有益活性。 为了更好地控制治疗效果，过去几十年来进行了表征特定分子并描述其个别活性的研究。 这些研究似乎强调了天然产物作为抗氧化剂和消炎剂特别有效。 在本系统综述中，我们旨在鉴定有效的抗炎天然产物，并将其功效与其化学结构和理化性质相关联。 为了鉴定这些化合物，我们进行了全面的文献搜索以找到那些研究，其中使用剂量反应说明和阳性对照参考化合物对观察到的活性进行基准测试。 在分析的论文中，最初选择的研究中有7％满足了这些要求，并进行了进一步分析。 该分析表明，大多数选定的天然产物确实似乎具有抗炎活性，尤其是抗氧化特性。 此外，在所有测试的测定中，有14％的天然产物优于其余的天然产物，并且作为新的抗炎药是有吸引力的候选物。

关键词: 天然产物，抗炎活性，结构活性关系，理化性质，生物学测定，治疗效果。

« Previous Next »
[1]
Faulkenberg, T. Traditional and Complementary Medicine policy.MDS-3 Manag. Access to Med. Heal. Technol, 3re ed.; Embrey, M., Ed.; Management Sciences for Health: Arlington, VA, , 2012; pp. 1-17.
[2]
Pubmed, N.I.H. NIH. Pubmed 2013.http://www.ncbi.nlm.nih.gov/pubmed [Accessed July 22, 2013];
[3]
Fürst,, R.; Zündorf, I. Plant-derived anti-inflammatory compounds: hopes and disappointments regarding the translation of preclinical knowledge into clinical progress. Mediators Inflamm., 2014, 2014146832
[http://dx.doi.org/10.1155/2014/146832] [PMID: 24987194]
[4]
Rice-Evans, C.A.; Miller, N.J.; Paganga, G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med., 1996, 20(7), 933-956.
[http://dx.doi.org/10.1016/0891-5849(95)02227-9] [PMID: 8743980]
[5]
Gautam, R.; Jachak, S.M. Recent developments in anti-inflammatory natural products. Med. Res. Rev., 2009, 29(5), 767-820.
[http://dx.doi.org/10.1002/med.20156] [PMID: 19378317]
[6]
Quideau, S.; Deffieux, D.; Douat-Casassus, C.; Pouységu, L. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew. Chem. Int. Ed. Engl., 2011, 50(3), 586-621.
[http://dx.doi.org/10.1002/anie.201000044] [PMID: 21226137]
[7]
Thomson Reuters. Web of Knowledge, 2013.www.webofknowledge.com
[8]
Abdelwahab, S.I.; Hassan, L.E.A.; Sirat, H.M.; Yagi, S.M.A.; Koko, W.S.; Mohan, S.; Taha, M.M.; Ahmad, S.; Chuen, C.S.; Narrima, P.; Rais, M.M.; Hadi, A.H. Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia, 2011, 82(8), 1190-1197.
[http://dx.doi.org/10.1016/j.fitote.2011.08.002] [PMID: 21871542]
[9]
Ashalatha, K.; Venkateswarlu, Y.; Priya, A.M.; Lalitha, P.; Krishnaveni, M.; Jayachandran, S. Anti inflammatory potential of Decalepis hamiltonii (Wight and Arn) as evidenced by down regulation of pro inflammatory cytokines-TNF-alpha and IL-2. J. Ethnopharmacol., 2010, 130(1), 167-170.
[http://dx.doi.org/10.1016/j.jep.2010.04.022] [PMID: 20434534]
[10]
Ban, J.O.; Oh, J.H.; Kim, T.M.; Kim, D.J.; Jeong, H-S.; Han, S.B.; Hong, J.T. Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfur compound isolated from garlic via inhibition of NF-kappa B. Arthritis Res. Ther., 2009, 11(5), R145.
[http://dx.doi.org/10.1186/ar2819] [PMID: 19788760]
[11]
Bao, L.; Yao, X.; Xu, J.; Guo, X.; Liu, H.; Kurihara, H. Effects of Pithecellobium clypearia Benth extract and its main components on inflammation and allergy. Fitoterapia, 2009, 80(6), 349-353.
[http://dx.doi.org/10.1016/j.fitote.2009.04.009] [PMID: 19427894]
[12]
Baolin, L.; Inami, Y.; Tanaka, H.; Inagaki, N.; Iinuma, M.; Nagai, H. Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro. Planta Med., 2004, 70(4), 305-309.
[http://dx.doi.org/10.1055/s-2004-818940] [PMID: 15095144]
[13]
Bas, E.; Recio, M.C.; Abdallah, M.; Máñez, S.; Giner, R.M.; Cerdá-Nicolás, M.; Ríos, J.L. Inhibition of the pro-inflammatory mediators production and anti-inflammatory effect of the iridoid scrovalentinoside. J. Ethnopharmacol., 2007, 110(3), 419-427.
[http://dx.doi.org/10.1016/j.jep.2006.09.038] [PMID: 17112695]
[14]
Bose, S.K.; Dewanjee, S.; Sahu, R.; Dey, S.P. Effect of bergapten from Heracleum nepalense root on production of proinflammatory cytokines. Nat. Prod. Res., 2011, 25(15), 1444-1449.
[http://dx.doi.org/10.1080/14786410902800665] [PMID: 19662568]
[15]
Capasso, R.; Borrelli, F.; Aviello, G.; Romano, B.; Scalisi, C.; Capasso, F.; Izzo, A.A. Cannabidiol, extracted from Cannabis sativa, selectively inhibits inflammatory hypermotility in mice. Br. J. Pharmacol., 2008, 154(5), 1001-1008.
[http://dx.doi.org/10.1038/bjp.2008.177] [PMID: 18469842]
[16]
Chandrasekaran, C.V.; Thiyagarajan, P.; Deepak, H.B.; Agarwal, A. In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract. Int. Immunopharmacol., 2011, 11(1), 79-84.
[http://dx.doi.org/10.1016/j.intimp.2010.10.009] [PMID: 21034865]
[17]
Chao, K-P.; Hua, K-F.; Hsu, H-Y.; Su, Y-C.; Chang, S-T. Anti-inflammatory activity of sugiol, a diterpene isolated from Calocedrus formosana bark. Planta Med., 2005, 71(4), 300-305.
[http://dx.doi.org/10.1055/s-2005-864094] [PMID: 15856404]
[18]
Chen, C-Y.; Peng, W-H.; Wu, L-C.; Wu, C-C.; Hsu, S-L. Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro: implications for therapy of lung fibrosis. J. Agric. Food Chem., 2010, 58(22), 11653-11661.
[http://dx.doi.org/10.1021/jf1031668] [PMID: 20958047]
[19]
Chi, Y.S.; Lim, H.; Park, H.; Kim, H.P. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem. Pharmacol., 2003, 66(7), 1271-1278.
[http://dx.doi.org/10.1016/S0006-2952(03)00463-5] [PMID: 14505806]
[20]
Chung, K-O.; Kim, B-Y.; Lee, M-H.; Kim, Y-R.; Chung, H-Y.; Park, J-H.; Moon, J.O. In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L. J. Pharm. Pharmacol., 2003, 55(12), 1695-1700.
[http://dx.doi.org/10.1211/0022357022313] [PMID: 14738598]
[21]
Corea, G.; Fattorusso, E.; Lanzotti, V.; Di Meglio, P.; Maffia, P.; Grassia, G.; Ialenti, A.; Ianaro, A. Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent. J. Med. Chem., 2005, 48(22), 7055-7062.
[http://dx.doi.org/10.1021/jm050321r] [PMID: 16250665]
[22]
Dugasani, S.; Pichika, M.R.; Nadarajah, V.D.; Balijepalli, M.K.; Tandra, S.; Korlakunta, J.N. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J. Ethnopharmacol., 2010, 127(2), 515-520.
[http://dx.doi.org/10.1016/j.jep.2009.10.004] [PMID: 19833188]
[23]
Enomoto, R.; Sugahara, C.; Suzuki, C.; Nagase, I.; Takamura, Y.; Yoshikawa, A.; Hosoda, A.; Hirano, H.; Yokoi, T.; Lee, E. Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. J. Pharmacol. Sci., 2007, 104(4), 355-365.
[http://dx.doi.org/10.1254/jphs.FP0061501] [PMID: 17690528]
[24]
Fang, S-H.; Rao, Y.K.; Tzeng, Y-M. Anti-oxidant and inflammatory mediators growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J. Ethnopharmacol., 2008, 116(2), 333-340.
[http://dx.doi.org/10.1016/j.jep.2007.11.040] [PMID: 18187278]
[25]
Fernandez-Arche, A.; Saenz, M.T.; Arroyo, M.; de la Puerta, R.; Garcia, M.D. Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. Phytomedicine, 2010, 17(2), 146-148.
[http://dx.doi.org/10.1016/j.phymed.2009.05.009] [PMID: 19577446]
[26]
Fouche, G.; Nieuwenhuizen, N.; Maharaj, V.; van Rooyen, S.; Harding, N.; Nthambeleni, R.; Jayakumar, J.; Kirstein, F.; Emedi, B.; Meoni, P. Investigation of in vitro and in vivo anti-asthmatic properties of Siphonochilus aethiopicus. J. Ethnopharmacol., 2011, 133(2), 843-849.
[http://dx.doi.org/10.1016/j.jep.2010.11.014] [PMID: 21075193]
[27]
Gao, H.; Zhao, F.; Chen, G-D.; Chen, S-D.; Yu, Y.; Yao, Z-H.; Lau, B.W.; Wang, Z.; Li, J.; Yao, X.S. Bidesmoside triterpenoid glycosides from Stauntonia chinensis and relationship to anti-inflammation. Phytochemistry, 2009, 70(6), 795-806.
[http://dx.doi.org/10.1016/j.phytochem.2009.04.005] [PMID: 19427657]
[28]
Guo, L.Y.; Hung, T.M.; Bae, K.H.; Shin, E.M.; Zhou, H.Y.; Hong, Y.N.; Kang, S.S.; Kim, H.P.; Kim, Y.S. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur. J. Pharmacol., 2008, 591(1-3), 293-299.
[http://dx.doi.org/10.1016/j.ejphar.2008.06.074] [PMID: 18625216]
[29]
HernAndez, V.; Máñez, S.; Recio, M.C.; Giner, R.M.; Ríos,, J.L. Anti-inflammatory profile of dehydrocostic acid, a novel sesquiterpene acid with a pharmacophoric conjugated diene. Eur. J. Pharm. Sci., 2005, 26(2), 162-169.
[http://dx.doi.org/10.1016/j.ejps.2005.05.007] [PMID: 15982859]
[30]
Hou, Y-C.; Liou, K-T.; Chern, C-M.; Wang, Y-H.; Liao, J-F.; Chang, S.; Chou, Y.H.; Shen, Y.C. Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-IB and STAT-1 activation. Phytomedicine, 2010, 17(12), 963-973.
[http://dx.doi.org/10.1016/j.phymed.2010.03.012] [PMID: 20833521]
[31]
Jan, K-C.; Ku, K-L.; Chu, Y-H.; Hwang, L.S.; Ho, C-T. Tissue distribution and elimination of estrogenic and anti-inflammatory catechol metabolites from sesaminol triglucoside in rats. J. Agric. Food Chem., 2010, 58(13), 7693-7700.
[http://dx.doi.org/10.1021/jf1009632] [PMID: 20524667]
[32]
Kenny, O.M.; McCarthy, C.M.; Brunton, N.P.; Hossain, M.B.; Rai, D.K.; Collins, S.G.; Jones, P.W.; Maguire, A.R.; OBrien, N.M. Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and raw 264.7 mouse macrophages. Life Sci., 2013, 92(13), 775-782.
[http://dx.doi.org/10.1016/j.lfs.2013.02.006] [PMID: 23454444]
[33]
Khan, I.; Nisar, M.; Shah, M.R.; Shah, H.; Gilani, S.N.; Gul, F.; Abdullah, S.M.; Ismail, M.; Khan, N.; Kaleem, W.A.; Qayum, M.; Khan, H.; Obaidullah, S.; Ullah, M. Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana. Zucc. Fitoterapia, 2011, 82(7), 1003-1007.
[http://dx.doi.org/10.1016/j.fitote.2011.06.003] [PMID: 21699963]
[34]
Khan, S.; Choi, R.J.; Shehzad, O.; Kim, H.P.; Islam, M.N.; Choi, J.S.; Kim, Y.S. Molecular mechanism of capillarisin-mediated inhibition of MyD88/TIRAP inflammatory signaling in in vitro and in vivo experimental models. J. Ethnopharmacol., 2013, 145(2), 626-637.
[http://dx.doi.org/10.1016/j.jep.2012.12.001] [PMID: 23237934]
[35]
Kourounakis, A.P.; Assimopoulou, A.N.; Papageorgiou, V.P.; Gavalas, A.; Kourounakis, P.N. Alkannin and shikonin: effect on free radical processes and on inflammation - a preliminary pharmacochemical investigation. Arch. Pharm. (Weinheim), 2002, 335(6), 262-266.
[http://dx.doi.org/10.1002/1521-4184(200208)335:6<262:AID-ARDP262>3.0.CO;2-Y] [PMID: 12210768]
[36]
Lu, Y.; Xiao, J.; Wu, Z-W.; Wang, Z-M.; Hu, J.; Fu, H-Z.; Chen, Y.Y.; Qian, R.Q. Kirenol exerts a potent anti-arthritic effect in collagen-induced arthritis by modifying the T cells balance. Phytomedicine, 2012, 19(10), 882-889.
[http://dx.doi.org/10.1016/j.phymed.2012.04.010] [PMID: 22673798]
[37]
Mengoni, E.S.; Vichera, G.; Rigano, L.A.; Rodriguez-Puebla, M.L.; Galliano, S.R.; Cafferata, E.E.; Pivetta, O.H.; Moreno, S.; Vojnov, A.A. Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L. Fitoterapia, 2011, 82(3), 414-421.
[http://dx.doi.org/10.1016/j.fitote.2010.11.023] [PMID: 21129455]
[38]
Mnonopi, N.; Levendal, R-A.; Davies-Coleman, M.T.; Frost, C.L. The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts. J. Ethnopharmacol., 2011, 138(1), 67-75.
[http://dx.doi.org/10.1016/j.jep.2011.08.041] [PMID: 21893184]
[39]
Muhammad, I.; Takamatsu, S.; Walker, L.A.; Mossa, J.S.; Fong, H.H.S.; El-Feraly, F.S. Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata. Phytother. Res., 2003, 17(8), 887-891.
[http://dx.doi.org/10.1002/ptr.1237] [PMID: 13680818]
[40]
Nardi, G.M.; Siqueira, Junior, J.M.; Delle Monache, F.; Pizzolatti, M.G.; Ckless, K.; Ribeiro-do-Valle, R.M. Antioxidant and anti-inflammatory effects of products from Croton celtidifolius Bailon on carrageenan-induced pleurisy in rats. Phytomedicine, 2007, 14(2-3), 115-122.
[http://dx.doi.org/10.1016/j.phymed.2006.03.002] [PMID: 16962304]
[41]
Njamen, D.; Talla, E.; Mbafor, J.T.; Fomum, Z.T.; Kamanyi, A.; Mbanya, J-C.; Cerdá-Nicolás, M.; Giner, R.M.; Recio, M.C.; Ríos, J.L. Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii. Eur. J. Pharmacol., 2003, 468(1), 67-74.
[http://dx.doi.org/10.1016/S0014-2999(03)01664-9] [PMID: 12729844]
[42]
Oh, S-W.; Cha, J-Y.; Jung, J-E.; Chang, B-C.; Kwon, H-J.; Lee, B-R.; Kim, D.Y. Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition. J. Ethnopharmacol., 2011, 136(3), 414-421.
[http://dx.doi.org/10.1016/j.jep.2010.07.026] [PMID: 20643202]
[43]
Okoye, F.B.C.; Osadebe, P.O.; Proksch, P.; Edrada-Ebel, R.A.; Nworu, C.S.; Esimone, C.O. Anti-inflammatory and membrane-stabilizing stigmastane steroids from Alchornea floribunda leaves. Planta Med., 2010, 76(2), 172-177.
[http://dx.doi.org/10.1055/s-0029-1186032] [PMID: 19688687]
[44]
Olajide, O.A.; Ajayi, A.M.; Wright, C.W. Anti-inflammatory properties of cryptolepine. Phytother. Res., 2009, 23(10), 1421-1425.
[http://dx.doi.org/10.1002/ptr.2794] [PMID: 19288476]
[45]
Ospina, L.F.; Calle, J.; Arteaga, L.; Pinzón, R.; Alcaraz, M.J.; Payá, M. Inhibition of acute and chronic inflammatory responses by the hydroxybenzoquinonic derivative rapanone. Planta Med., 2001, 67(9), 791-795.
[http://dx.doi.org/10.1055/s-2001-18839] [PMID: 11745012]
[46]
Ren, J.; Han, E.J.; Chung, S.H. In vivo and in vitro anti-inflammatory activities of I-linolenic acid isolated from Actinidia polygama fruits. Arch. Pharm. Res., 2007, 30(6), 708-714.
[http://dx.doi.org/10.1007/BF02977632] [PMID: 17679548]
[47]
Sala, A.; Recio, M.C.; Schinella, G.R.; Máñez, S.; Giner, R.M.; Cerdá-Nicolás, M.; Rosí, J.L. Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside. Eur. J. Pharmacol., 2003, 461(1), 53-61.
[http://dx.doi.org/10.1016/S0014-2999(02)02953-9] [PMID: 12568916]
[48]
Santa-Cecília, F.V.; Santos, G.B.; Fuzissaki, C.N.; Derogis, P.B.; Freitas, L.A.; Gontijo, V.S.; Stringheta, P.C.; Nagem, T.J.; Brigagão, M.R.; Santos, M.H. 7-epiclusianone, the natural prenylated benzophenone, inhibits superoxide anions in the neutrophil respiratory burst. J. Med. Food, 2012, 15(2), 200-205.
[http://dx.doi.org/10.1089/jmf.2011.0043] [PMID: 22191630]
[49]
Subramoniam, A.; Asha, V.V.; Nair, S.A.; Sasidharan, S.P.; Sureshkumar, P.K.; Rajendran, K.N.; Karunagaran, D.; Ramalingam, K. Chlorophyll revisited: anti-inflammatory activities of chlorophyll a and inhibition of expression of TNF-α gene by the same. Inflammation, 2012, 35(3), 959-966.
[http://dx.doi.org/10.1007/s10753-011-9399-0] [PMID: 22038065]
[50]
Taha, M.M.E.; Salga, M.S.; Ali, H.M.; Abdulla, M.A.; Abdelwahab, S.I.; Hadi, A.H.A. Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin. J. Ethnopharmacol., 2012, 141(1), 273-281.
[http://dx.doi.org/10.1016/j.jep.2012.02.030] [PMID: 22374081]
[51]
Wang, C-C.; Lai, J-E.; Chen, L-G.; Yen, K-Y.; Yang, L-L. Inducible nitric oxide synthase inhibitors of Chinese herbs. Part 2: naturally occurring furanocoumarins. Bioorg. Med. Chem., 2000, 8(12), 2701-2707.
[http://dx.doi.org/10.1016/S0968-0896(00)00200-5] [PMID: 11131161]
[52]
Zhang, B.; He, X-L.; Ding, Y.; Du, G-H. Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis: towards a better non-steroidal anti-inflammatory drug. Eur. J. Pharmacol., 2006, 530(1-2), 166-171.
[http://dx.doi.org/10.1016/j.ejphar.2005.11.030] [PMID: 16375889]
[53]
Bansal, Y.; Sethi, P.; Bansal, G. Coumarin: a potential nucleus for anti-inflammatory molecules. Med. Chem. Res., 2013, 22, 3049-3060.
[http://dx.doi.org/10.1007/s00044-012-0321-6]
[54]
Drugbank. Vitamin E n.d. https://www.drugbank.ca/drugs/DB00163[Accessed June 1, 2015]; .
[55]
Scientific Opinion on the re-evaluation of propyl gallate (E 310) as a food additive. EFSA J., 2014, 12, 3642-3687.
[http://dx.doi.org/10.2903/j.efsa.2014.3642]
[56]
Zaloga, G.P. Phytosterols, Lipid Administration, and Liver Disease During Parenteral Nutrition. JPEN J. Parenter. Enteral Nutr., 2015, 39(1)(Suppl.), 39S-60S.
[http://dx.doi.org/10.1177/0148607115595978] [PMID: 26177665]
[57]
Drugbank. Dexamethasone n.d. https://www.drugbank.ca/drugs/DB01234 [Accessed June 1, 2015];.
[58]
Drugbank. Hydrocortisone n.d. https://www.drugbank.ca/drugs/DB00741[Accessed June 1, 2015];.
[59]
Drugbank. Prednisolone n.d. https://www.drugbank.ca/drugs/DB00860[Accessed June 1, 2015];.
[60]
Gershenzon, J.; Dudareva, N. The function of terpene natural products in the natural world. Nat. Chem. Biol., 2007, 3(7), 408-414.
[http://dx.doi.org/10.1038/nchembio.2007.5] [PMID: 17576428]
[61]
Rivière, C.; Pawlus, A.D.; Mérillon, J-M. Natural stilbenoids: distribution in the plant kingdom and chemotaxonomic interest in Vitaceae. Nat. Prod. Rep., 2012, 29(11), 1317-1333.
[http://dx.doi.org/10.1039/c2np20049j] [PMID: 23014926]
[62]
Pietta, P.G. Flavonoids as antioxidants. J. Nat. Prod., 2000, 63(7), 1035-1042.
[http://dx.doi.org/10.1021/np9904509] [PMID: 10924197]
[63]
Butler, M.S.; Robertson, A.A.; Cooper, M.A. Natural product and natural product derived drugs in clinical trials. Nat. Prod. Rep., 2014, 31(11), 1612-1661.
[http://dx.doi.org/10.1039/C4NP00064A] [PMID: 25204227]
[64]
Caldwell, J.; Gardner, I.; Swales, N. An introduction to drug disposition: the basic principles of absorption, distribution, metabolism, and excretion. Toxicol. Pathol., 1995, 23(2), 102-114.
[http://dx.doi.org/10.1177/019262339502300202] [PMID: 7569663]
[65]
van de Waterbeemd, H.; Gifford, E. ADMET in silico modelling: towards prediction paradise? Nat. Rev. Drug Discov., 2003, 2(3), 192-204.
[http://dx.doi.org/10.1038/nrd1032] [PMID: 12612645]
[66]
ChemAxon. In: Instant J; Chem. Suite, 2015.
[67]
Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev., 2001, 46(1-3), 3-26.
[http://dx.doi.org/10.1016/S0169-409X(00)00129-0] [PMID: 11259830]
[68]
Waring, M.J. Defining optimum lipophilicity and molecular weight ranges for drug candidates -Molecular weight dependent lower logD limits based on permeability. Bioorg. Med. Chem. Lett., 2009, 19(10), 2844-2851.
[http://dx.doi.org/10.1016/j.bmcl.2009.03.109] [PMID: 19361989]
[69]
Johnson, T.W.; Dress, K.R.; Edwards, M. Using the Golden Triangle to optimize clearance and oral absorption. Bioorg. Med. Chem. Lett., 2009, 19(19), 5560-5564.
[http://dx.doi.org/10.1016/j.bmcl.2009.08.045] [PMID: 19720530]
[70]
Palm, K.; Stenberg, P.; Luthman, K.; Artursson, P. Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharm. Res., 1997, 14(5), 568-571.
[http://dx.doi.org/10.1023/A:1012188625088] [PMID: 9165525]
[71]
Veber, D.F.; Johnson, S.R.; Cheng, H-Y.; Smith, B.R.; Ward, K.W.; Kopple, K.D. Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem., 2002, 45(12), 2615-2623.
[http://dx.doi.org/10.1021/jm020017n] [PMID: 12036371]
[72]
Ritchie, T.J.; Macdonald, S.J.F. The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design? Drug Discov. Today, 2009, 14(21-22), 1011-1020.
[http://dx.doi.org/10.1016/j.drudis.2009.07.014] [PMID: 19729075]
[73]
Korhonen, R.; Lahti, A.; Kankaanranta, H.; Moilanen, E. Nitric oxide production and signaling in inflammation. Curr. Drug Targets Inflamm. Allergy, 2005, 4(4), 471-479.
[http://dx.doi.org/10.2174/1568010054526359] [PMID: 16101524]
[74]
Kedare, S.B.; Singh, R.P. Genesis and development of DPPH method of antioxidant assay. J. Food Sci. Technol., 2011, 48(4), 412-422.
[http://dx.doi.org/10.1007/s13197-011-0251-1] [PMID: 23572765]
[75]
Dröge, W. Free radicals in the physiological control of cell function. Physiol. Rev., 2002, 82(1), 47-95.
[http://dx.doi.org/10.1152/physrev.00018.2001] [PMID: 11773609]
[76]
Neurath, M.F.; Finotto, S. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev., 2011, 22(2), 83-89.
[http://dx.doi.org/10.1016/j.cytogfr.2011.02.003] [PMID: 21377916]
[77]
Hayden, M.S.; Ghosh, S. Shared principles in NF-kappaB signaling. Cell, 2008, 132(3), 344-362.
[http://dx.doi.org/10.1016/j.cell.2008.01.020] [PMID: 18267068]
[78]
Kawahara, K.; Hohjoh, H.; Inazumi, T.; Tsuchiya, S.; Sugimoto, Y. Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors. Biochim. Biophys. Acta, 2015, 1851(4), 414-421.
[http://dx.doi.org/10.1016/j.bbalip.2014.07.008] [PMID: 25038274]
[79]
Yokomizo, T.; Izumi, T.; Shimizu, T. Leukotriene B4: metabolism and signal transduction. Arch. Biochem. Biophys., 2001, 385(2), 231-241.
[http://dx.doi.org/10.1006/abbi.2000.2168] [PMID: 11368003]
[80]
Akdis, C.A.; Simons, F.E.R. Histamine receptors are hot in immunopharmacology. Eur. J. Pharmacol., 2006, 533(1-3), 69-76.
[http://dx.doi.org/10.1016/j.ejphar.2005.12.044] [PMID: 16448645]
[81]
Gad, S.C. The mouse ear swelling test (MEST) in the 1990s. Toxicology, 1994, 93(1), 33-46.
[http://dx.doi.org/10.1016/0300-483X(94)90194-5] [PMID: 7974503]
[82]
Morris, C.J. Carrageenan-Induced Paw Edema in the Rat and Mouse. Inflamm. Protoc; Humana Press: New Jersey, 2003, Vol. 225, pp. 115-122.
[83]
Martin, E.J.; Blaney, J.M.; Siani, M.A.; Spellmeyer, D.C.; Wong, A.K.; Moos, W.H. Measuring diversity: experimental design of combinatorial libraries for drug discovery. J. Med. Chem., 1995, 38(9), 1431-1436.
[http://dx.doi.org/10.1021/jm00009a003] [PMID: 7739001]
[84]
Ritchie, T.J.; Ertl, P.; Lewis, R. The graphical representation of ADME-related molecule properties for medicinal chemists. Drug Discov. Today, 2011, 16(1-2), 65-72.
[http://dx.doi.org/10.1016/j.drudis.2010.11.002] [PMID: 21074634]
[85]
Nantasenamat, C.; Isarankura-Na-Ayudhya, C.; Prachayasittikul, V. Advances in computational methods to predict the biological activity of compounds. Expert Opin. Drug Discov., 2010, 5(7), 633-654.
[http://dx.doi.org/10.1517/17460441.2010.492827] [PMID: 22823204]
[86]
Dearden, J.C.; Cronin, M.T.D.; Kaiser, K.L.E. How not to develop a quantitative structure-activity or structure-property relationship (QSAR/QSPR). SAR QSAR Environ. Res., 2009, 20(3-4), 241-266.
[http://dx.doi.org/10.1080/10629360902949567] [PMID: 19544191]
[87]
Dobson, C.M. Chemical space and biology. Nature, 2004, 432(7019), 824-828.
[http://dx.doi.org/10.1038/nature03192] [PMID: 15602547]
[88]
Yokozawa, T.; Chen, C.P.; Dong, E.; Tanaka, T.; Nonaka, G.I.; Nishioka, I. Study on the inhibitory effect of tannins and flavonoids against the 1,1-diphenyl-2 picrylhydrazyl radical. Biochem. Pharmacol., 1998, 56(2), 213-222.
[http://dx.doi.org/10.1016/S0006-2952(98)00128-2] [PMID: 9698075]
[89]
Burda, S.; Oleszek, W.; Oleszek, W.; Oleszek, W. Antioxidant and antiradical activities of flavonoids. J. Agric. Food Chem., 2001, 49(6), 2774-2779.
[http://dx.doi.org/10.1021/jf001413m] [PMID: 11409965]
[90]
Furuno, K.; Akasako, T.; Sugihara, N. The contribution of the pyrogallol moiety to the superoxide radical scavenging activity of flavonoids. Biol. Pharm. Bull., 2002, 25(1), 19-23.
[http://dx.doi.org/10.1248/bpb.25.19] [PMID: 11824550]
[91]
Kumari, A.; Kumar, V.; Yadav, S.K. Nanotechnology: A tool to enhance therapeutic values of natural plant products. Trends Med Res, 2012, 7, 34-42.
[http://dx.doi.org/10.3923/tmr.2012.34.42]

Rights & Permissions Print Cite
Article Metrics
69
3
© 2025 Bentham Science Publishers | Privacy Policy