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Review Article

过度激活Nrf2 / ARE系统的膳食补充剂的作用C

卷 27, 期 13, 2020

页: [2077 - 2094] 页: 18

弟呕挨: 10.2174/0929867326666190517113533

价格: $65

摘要

背景：炎症是人类健康中最容易被误解的方面之一。人们被鼓励吃抗氧化能力强的食物，并出现了总抗氧化能力的体外测试。它们基于测量与食物中的抗氧化剂直接反应而氧化的测试化合物的破坏程度。许多膳食补充剂进入市场。它们包含纯净的抗氧化剂，例如白藜芦醇和EGCG，许多人现在并且仍然广泛认为它们在任何剂量下都相当健康。 方法：系统地检索有关炎症和Nrf2 / ARE抗氧化系统的文献。从著名的，经过同行评审的期刊中获取文章并进行阅读。从他们那里获得的信息被用来撰写这篇评论文章。 结果：阅读了150余篇文章和书籍。从他们那里获得的信息表明，很少有饮食中的抗氧化剂通过直接与活性氧和氮物种（RONS）反应而发挥作用。相反，大多数有效的抗氧化剂可激活内源性Nrf2 / ARE抗氧化剂系统。这有助于防止阴燃性发炎及其引起的疾病。但是，当Nrf2 / ARE抗氧化剂系统过度激活或组成性激活时，它们可能导致其中一些疾病，包括多种类型的多药耐药性癌症，自身免疫性疾病，神经退行性疾病和心血管疾病。 结论：尽管绿茶以及许多水果，蔬菜和香料非常健康，但提供高剂量抗氧化剂的膳食补充剂可能并非如此。被诊断出患有癌症并计划开始化学疗法和/或放射疗法的人应该避免使用此类补充剂。这是因为耐多药的肿瘤会劫持并过度激活Nrf2 / ARE抗氧化剂系统。

关键词: Nrf2 / ARE，抗氧化剂，二甲双胍，ECGC，白藜芦醇，耐多药癌症，膳食补充剂，绿茶。

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