Abstract
Heterocycles are very common substructures in a number of pharmaceuticals. Over the past several years, the use of palladium-catalyzed oxidative cyclization for heterocyclic synthesis has become much more prevalent. This review collects recent reports using palladium catalysis to synthesize a wide variety of heterocyclic scaffolds. Many of these reactions use oxygen as the terminal oxidant. Some salient mechanistic features are discussed.
Keywords: Oxidation, palladium, palladium-catalyzed, carbocycle, heterocycle, synthesis.
Graphical Abstract
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Call for Papers in Thematic Issues
31 December, 2024
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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