摘要
背景:大量研究已经分析了使用不同的隐形眼镜(CL)或护理液的影响,以及与CL佩戴相关的不适或疾病,这些炎症或炎性介质释放到眼泪中。目的:总结与CL使用相关的眼泪炎症分子的公开数据。 方法:进行PubMed-NCBI检索,选择那些进行原始调查的出版物,包括分析CL佩戴者的泪液炎症介质。 结果:1990年至2019年共收录了43篇文章。据报道,佩戴水凝胶CL,坚硬的透气性CL和圆锥形角膜患者不规则角膜的特殊设计(圆锥形圆锥形CL,混合性CL,背负式和巩膜性CL)可改变眼泪中几种分子的浓度。而且,似乎会影响佩戴时间和时间表,CL材料和设计以及所用的护理液。关于CL不适,其与炎性介质的关系尚不清楚。但是,一些与CL磨损相关的疾病,例如巨乳头结膜炎,CL引起的急性红眼,CL引起的周围性溃疡和棘阿米巴角膜炎,与某些炎症介质的释放有关,这些介质可能是潜在的生物标志物。 结论:有证据表明,CL佩戴的不同方面改变了眼泪中的炎症介质分布,这可能表明泪液功能单元处于炎症状态。但是,需要进行更多的研究,以更好地了解这种炎症过程如何发挥作用,以及对CL磨损不同方面的影响。
关键词: 隐形眼镜,泪液,炎症,介质,生物标志物,分子,CL不适。
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