摘要
背景:抗氧化剂是在多种细胞功能中起关键作用的多方面分子。 到目前为止,关于它们参与许多与衰老相关的过程的知识已广为人知,这些过程包括血管损伤,神经退行性疾病和癌症。 这些化合物与最近的发现有关,最近表明它们对某些微生物病原体(包括金黄色葡萄球菌,变形链球菌和铜绿假单胞菌)影响生物膜形成的能力具有新兴的应用领域。 方法:使用重点评论问题对书目数据库进行结构化搜索,以查找经过同行评审的研究文献。 使用标准工具评估检索到的论文的质量。 结果:从公开数据库中摘录并在过去的15年中发表的165篇论文被纳入本综述,重点评估抗氧化剂化合物的抗微生物和抗生物膜活性,包括维生素,类黄酮,非类黄酮多酚和抗氧化剂 聚合物。 确定了一些重要的抗氧化剂化合物,特别是维生素C和酚酸的作用机理。 结论:这篇综述的结果证实了使用天然抗氧化剂作为抗微生物/抗生物膜化合物的潜在益处。 通常,发现革兰氏阳性细菌比革兰氏阴性细菌对抗氧化剂更敏感。 还已经开发出主要由多糖与抗氧化剂分子的官能化形成的抗氧化剂聚合物体系。 此类系统在临床中的应用可以克服与抗氧化剂全身性输送有关的一些问题,例如吸收不良,生物活性丧失和半衰期有限。 然而,专注于研究抗氧化剂聚合物的抗生物膜活性的研究仍然非常有限,因此强烈鼓励进行研究,以便为将抗氧化剂聚合物用于治疗基于生物膜的感染奠定基础。
关键词: 天然抗氧化剂,抗氧化剂聚合物,抗坏血酸,多酚,类黄酮,微生物生物膜,感染。
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