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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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Review Article

The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide’s Toxicity

Author(s): Youhan Wang*, Biao Wang* and Xiaobin Yang*

Volume 15, Issue 1, 2020

Page: [18 - 23] Pages: 6

DOI: 10.2174/1574888X14666190301155810

Price: $65

Abstract

Triptolide (TPL), the active component of Tripterygium wilfordii Hook F (Twhf) has been used to treat cancer and bone loss conditions for over two hundred years in traditional Chinese medicine (TCM). In this paper, we reviewed the specific molecular mechanisms in the treatment of cancer, bone loss and cardiovascular disease. In addition, we analyze the toxicity of TPL and collect some optimized derivatives extracted from TPL. Although positive results were obtained in most cell culture and animal studies, further studies are needed to substantiate the beneficial effects of TPL.

Keywords: Triptolide, bone loss, anti-cancer, cardiovascular disease, toxicity, cancer.

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