Crystal Structures of Acridines Complexed with Nucleic Acids

Adrienne      Adams

doi:10.2174/0929867023369259

Abstract

Acridines have been used as chemotherapeutic agents against bacteria, protozoa and fungi, and they now find important use as anticancer drugs. There is a paucity of crystal structures of acridine-DNA complexes above the dinucleotide level, but recent structures of acridinecarboxamide topoisomerase II poisons complexed to hexanucleotides have allowed a molecular rationalization of their structure-activity relationships for cytotoxicity and for their kinetics of DNA binding.

Keywords: acridines, crystal structures, nucleic acids, DNA, complexes, acridine-4-carboxamides

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Current Medicinal Chemistry

Title: Crystal Structures of Acridines Complexed with Nucleic Acids

Volume: 9 Issue: 18

Author(s): Adrienne Adams

Affiliation:

Keywords: acridines, crystal structures, nucleic acids, DNA, complexes, acridine-4-carboxamides

Abstract: Acridines have been used as chemotherapeutic agents against bacteria, protozoa and fungi, and they now find important use as anticancer drugs. There is a paucity of crystal structures of acridine-DNA complexes above the dinucleotide level, but recent structures of acridinecarboxamide topoisomerase II poisons complexed to hexanucleotides have allowed a molecular rationalization of their structure-activity relationships for cytotoxicity and for their kinetics of DNA binding.

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Adams Adrienne, Crystal Structures of Acridines Complexed with Nucleic Acids, Current Medicinal Chemistry 2002; 9 (18) . https://dx.doi.org/10.2174/0929867023369259