摘要
由于碳纳米管(CNTs)的成功应用,石墨烯和氧化石墨烯(GO)作为一种创新的药物纳米载体在以往的研究中得到了广泛的研究,可装载多种治疗药物、抗癌药物、低可溶性药物、抗生素、抗体、多肽、DNA、RNA和基因。石墨烯由于表面积大,具有超高的载药效率。石墨烯和氧化石墨烯由于其独特的特性而被广泛应用于生物医学领域: 二维平面结构、宽表面积、化学和机械稳定性、卓越的导电性和良好的生物相容性。由于这些独特的品质,氧化石墨烯的应用提供了先进的药物运输框架和运输广泛的治疗。在这篇综述中,我们讨论了石墨烯和氧化石墨烯在药物递送和纳米医学中的最新进展和改进。首先,我们描述了什么是石墨烯和氧化石墨烯。之后,我们讨论了石墨烯氧化物作为药物载体的性质,在药物传输应用中,利用靶向药物传输,抗癌药物的传送,化学控制药物释放,不同的药物的协同转运,氧化石墨烯与碳纳米管的比较,纳米石墨烯以及纳米石墨烯的毒性。最后,我们对目前的扩张和未来的潜在前景进行了总结。
关键词: 石墨烯,氧化石墨烯,纳米药物,给药系统,石墨烯DDS,高定向裂解石墨(HOPG)。
[http://dx.doi.org/10.1021/cr900070d] [PMID: 19610631]
[http://dx.doi.org/10.1126/science.1158877]
[http://dx.doi.org/10.1038/nmat1849] [PMID: 17330084]
[http://dx.doi.org/10.1038/nnano.2007.432] [PMID: 18654440]
[http://dx.doi.org/10.1039/c0jm02827d]
[http://dx.doi.org/10.1038/ncomms2818] [PMID: 23653189]
[http://dx.doi.org/10.1039/C3CS60260E] [PMID: 24280706]
[http://dx.doi.org/10.1021/nn1006495] [PMID: 20462272]
[http://dx.doi.org/10.1103/PhysRevLett.102.195505] [PMID: 19518972]
[http://dx.doi.org/10.1038/nature14015] [PMID: 25470058]
[http://dx.doi.org/10.1021/nl061594s] [PMID: 17163744]
[http://dx.doi.org/10.1016/j.jallcom.2014.02.103]
[http://dx.doi.org/10.1002/adma.200900323]
[http://dx.doi.org/10.1021/nn8004922] [PMID: 19206466]
[http://dx.doi.org/10.1016/j.jallcom.2015.07.100]
[http://dx.doi.org/10.1021/nl1022139] [PMID: 20698639]
[http://dx.doi.org/10.1126/science.1184167]
[http://dx.doi.org/10.1016/j.carbon.2015.08.002]
[http://dx.doi.org/10.1016/j.snb.2012.07.092]
[http://dx.doi.org/10.1021/jz300358t] [PMID: 26291854]
[http://dx.doi.org/10.1039/c2sc20205k]
[http://dx.doi.org/10.1126/science.1194975] [PMID: 21292974]
[http://dx.doi.org/10.1038/nature04233] [PMID: 16281030]
[http://dx.doi.org/10.1126/science.1102896] [PMID: 15499015]
[http://dx.doi.org/10.1126/science.1078842] [PMID: 12610297]
[http://dx.doi.org/10.1038/nnano.2008.215] [PMID: 18772919]
[http://dx.doi.org/10.1126/science.1171245] [PMID: 19423775]
[http://dx.doi.org/10.1126/science.1125925] [PMID: 16614173]
[http://dx.doi.org/10.1038/nature09211] [PMID: 20651687]
[http://dx.doi.org/10.1002/anie.200352855] [PMID: 14755713]
[http://dx.doi.org/10.1038/nchem.891] [PMID: 21160519]
[http://dx.doi.org/10.1021/nl0717715] [PMID: 17944523]
[http://dx.doi.org/10.1016/j.carbon.2007.02.034]
[http://dx.doi.org/10.1007/s11051-014-2474-3]
[http://dx.doi.org/10.1021/jp040650f]
[http://dx.doi.org/10.1016/0039-6028(92)90183-7]
[http://dx.doi.org/10.1038/nature07719] [PMID: 19145232]
[http://dx.doi.org/10.1016/0039-6028(79)90330-3]
[http://dx.doi.org/10.1098/rstl.1859.0013]
[http://dx.doi.org/10.1021/ja01539a017]
[http://dx.doi.org/10.1002/cber.18980310237]
[http://dx.doi.org/10.1002/zaac.19372340405]
[http://dx.doi.org/10.1039/C4CS00455H] [PMID: 26024242]
[http://dx.doi.org/10.1039/C5CS00021A] [PMID: 25812036]
[http://dx.doi.org/10.1039/C5CS00147A] [PMID: 26051987]
[http://dx.doi.org/10.1039/c0cs00079e] [PMID: 21283849]
[http://dx.doi.org/10.1039/C1CS15270J] [PMID: 22143223]
[http://dx.doi.org/10.1021/nn103428k] [PMID: 21226512]
[http://dx.doi.org/10.1016/j.carbon.2011.11.010]
[http://dx.doi.org/10.1038/nchem.281] [PMID: 21378895]
[http://dx.doi.org/10.1016/j.carbon.2008.08.013]
[http://dx.doi.org/10.1021/nn901204c] [PMID: 20047271]
[http://dx.doi.org/10.1016/j.carbon.2010.02.001]
[http://dx.doi.org/10.1021/jp060936f] [PMID: 16640401]
[http://dx.doi.org/10.1103/PhysRevB.69.155406]
[http://dx.doi.org/10.1021/ja205168x] [PMID: 21846143]
[http://dx.doi.org/10.1039/c1cc13312h] [PMID: 21779603]
[http://dx.doi.org/10.1021/jp909284g]
[http://dx.doi.org/10.1039/C4RA06852A]
[http://dx.doi.org/10.1016/j.carbon.2011.02.071]
[http://dx.doi.org/10.1016/j.carbon.2012.09.060]
[http://dx.doi.org/10.1016/j.nantod.2009.12.009]
[http://dx.doi.org/10.1002/adma.200901942] [PMID: 20217699]
[http://dx.doi.org/10.1021/jz100790y]
[http://dx.doi.org/10.1002/adma.200901902] [PMID: 20217732]
[http://dx.doi.org/10.1021/ja902348k] [PMID: 19601624]
[http://dx.doi.org/10.1002/cssc.201100467] [PMID: 22415902]
[http://dx.doi.org/10.1021/jp305403r]
[http://dx.doi.org/10.1007/s11237-012-9235-0]
[http://dx.doi.org/10.1002/adom.201400560]
[http://dx.doi.org/10.1039/C5RA24577J]
[http://dx.doi.org/10.1039/C6RA00426A]
[http://dx.doi.org/10.1016/j.matdes.2016.09.018]
[http://dx.doi.org/10.1016/j.electacta.2014.03.137]
[http://dx.doi.org/10.1016/j.carbon.2012.10.017]
[http://dx.doi.org/10.1016/j.yofte.2014.07.005]
[http://dx.doi.org/10.1016/S1369-7021(03)00632-1]
[http://dx.doi.org/10.1103/PhysRevB.80.165207]
[http://dx.doi.org/10.1038/nature11458] [PMID: 23060189]
[http://dx.doi.org/10.1038/nnano.2008.280] [PMID: 18989334]
[http://dx.doi.org/10.1103/PhysRevLett.95.205501] [PMID: 16384068]
[http://dx.doi.org/10.1063/1.3126450]
[http://dx.doi.org/10.1016/j.electacta.2009.04.017]
[http://dx.doi.org/10.1103/PhysRevLett.98.186806] [PMID: 17501596]
[http://dx.doi.org/10.1103/PhysRevLett.97.236801] [PMID: 17280222]
[http://dx.doi.org/10.1021/acsnano.5b02337] [PMID: 26061778]
[http://dx.doi.org/10.1016/j.spmi.2016.08.044]
[http://dx.doi.org/10.1016/j.matlet.2012.05.074]
[http://dx.doi.org/10.1039/C5CP02014J] [PMID: 26033301]
[http://dx.doi.org/10.1016/j.ijhydene.2014.01.051]
[http://dx.doi.org/10.1016/j.jpowsour.2017.08.058]
[http://dx.doi.org/10.1016/j.jpowsour.2016.09.143]
[http://dx.doi.org/10.1021/acs.chemrev.7b00115] [PMID: 28753298]
[http://dx.doi.org/10.1016/j.jpowsour.2017.11.045]
[http://dx.doi.org/10.1016/j.carbon.2009.03.053]
[http://dx.doi.org/10.1002/aenm201300575]
[http://dx.doi.org/10.1002/adma.201300445] [PMID: 23606504]
[http://dx.doi.org/10.1016/j.electacta.2014.04.160]
[http://dx.doi.org/10.1016/j.apmt.2017.02.001]
[http://dx.doi.org/10.1002/cssc.200900106] [PMID: 19816895]
[http://dx.doi.org/10.1021/nn100740x] [PMID: 20455594]
[http://dx.doi.org/10.1016/j.jallcom.2017.04.308]
[http://dx.doi.org/10.1016/j.jcis.2017.03.002] [PMID: 28324727]
[http://dx.doi.org/10.1016/j.jallcom.2017.07.051]
[http://dx.doi.org/10.1016/j.pecs.2018.03.001]
[http://dx.doi.org/10.1016/j.jconrel.2016.02.015] [PMID: 26873333]
[http://dx.doi.org/10.1002/adom.201300317]
[http://dx.doi.org/10.1016/j.biopha.2017.07.122] [PMID: 28772213]
[http://dx.doi.org/10.1126/science.1063273] [PMID: 11441170]
[http://dx.doi.org/10.2174/1389450043345407] [PMID: 15216911]
[http://dx.doi.org/10.1166/jnn.2015.10614] [PMID: 26369109]
[http://dx.doi.org/10.1016/j.tibtech.2011.01.008] [PMID: 21397350]
[http://dx.doi.org/10.1002/adma.201203229] [PMID: 23161646]
[http://dx.doi.org/10.1002/adhm.201300023] [PMID: 23526812]
[http://dx.doi.org/10.1039/C2CS35342C] [PMID: 23059655]
[http://dx.doi.org/10.7150/thno.3642] [PMID: 22448195]
[http://dx.doi.org/10.2217/nnm.10.158] [PMID: 21385134]
[http://dx.doi.org/10.1517/17425247.2012.729575] [PMID: 23005029]
[http://dx.doi.org/10.1016/S1369-7021(11)70161-4]
[http://dx.doi.org/10.1039/C2TB00085G] [PMID: 32260810]
[http://dx.doi.org/10.1021/nn1007176] [PMID: 20481456]
[http://dx.doi.org/10.1038/nrd2614] [PMID: 18758474]
[http://dx.doi.org/10.1016/j.actbio.2013.08.016] [PMID: 23958782]
[http://dx.doi.org/10.1021/am303005j] [PMID: 23402618]
[http://dx.doi.org/10.1021/ac801118p] [PMID: 18771233]
[http://dx.doi.org/10.1002/jbm.a.33252] [PMID: 21997951]
[http://dx.doi.org/10.1016/j.carbon.2010.11.026]
[http://dx.doi.org/10.1021/jp806751k]
[http://dx.doi.org/10.1016/j.pmatsci.2012.03.002]
[http://dx.doi.org/10.1021/tx200339h] [PMID: 21954945]
[http://dx.doi.org/10.1021/nn202699t] [PMID: 21932790]
[http://dx.doi.org/10.1021/ar300199e] [PMID: 23163827]
[http://dx.doi.org/10.1038/nnano.2007.451] [PMID: 18654470]
[http://dx.doi.org/10.1039/c3nr02845c] [PMID: 23900571]
[http://dx.doi.org/10.1016/j.carbon.2014.10.017]
[http://dx.doi.org/10.1021/cr300335p] [PMID: 23452512]
[http://dx.doi.org/10.1088/0957-4484/23/41/415101] [PMID: 23010805]
[http://dx.doi.org/10.1088/0957-4484/23/46/465103] [PMID: 23093209]
[http://dx.doi.org/10.1021/nn403096s] [PMID: 23829596]
[http://dx.doi.org/10.1021/es403247k] [PMID: 24345218]
[http://dx.doi.org/10.1021/am200428v] [PMID: 21650218]
[http://dx.doi.org/10.1021/ie800886m]
[http://dx.doi.org/10.1021/la501075c] [PMID: 24924411]
[http://dx.doi.org/10.1021/nn406223e] [PMID: 24428340]
[http://dx.doi.org/10.1039/C2CC38417E] [PMID: 23232330]
[http://dx.doi.org/10.1021/la502952f] [PMID: 25109617]
[http://dx.doi.org/10.1016/j.carbon.2010.11.005]
[http://dx.doi.org/10.1002/anie.200460800] [PMID: 15558662]
[http://dx.doi.org/10.1016/j.clim.2006.06.006] [PMID: 16920030]
[http://dx.doi.org/10.1016/j.biomaterials.2005.02.038] [PMID: 15949555]
[http://dx.doi.org/10.1002/smll.200901680] [PMID: 20033930]
[http://dx.doi.org/10.7150/thno/v01p0240] [PMID: 21562631]
[http://dx.doi.org/10.1039/C0JM02494E]
[http://dx.doi.org/10.1002/anie.201105573] [PMID: 21990208]
[http://dx.doi.org/10.1093/jnci/85.4.271] [PMID: 8381186]
[http://dx.doi.org/10.2174/092986706777585004] [PMID: 16842195]
[http://dx.doi.org/10.1007/s12274-008-8021-8] [PMID: 20216934]
[http://dx.doi.org/10.1039/c1cc00075f] [PMID: 21451845]
[http://dx.doi.org/10.1002/adfm.201100078]
[http://dx.doi.org/10.1002/mame.201000307]
[http://dx.doi.org/10.1021/ja803688x] [PMID: 18661992]
[http://dx.doi.org/10.1021/bc200397j] [PMID: 22034966]
[http://dx.doi.org/10.1039/c2jm34494g]
[http://dx.doi.org/10.1021/la1042734] [PMID: 21182239]
[http://dx.doi.org/10.1039/c000051e] [PMID: 20309457]
[http://dx.doi.org/10.2174/092986711797287548] [PMID: 21864287]
[http://dx.doi.org/10.1088/0957-4484/23/35/355101] [PMID: 22875697]
[PMID: 22619524]
[http://dx.doi.org/10.1039/c2cs35146c] [PMID: 22648524]
[http://dx.doi.org/10.1002/smll.201001522] [PMID: 21360803]
[http://dx.doi.org/10.1002/smll.201100191] [PMID: 21538871]
[http://dx.doi.org/10.1016/j.carbon.2011.05.049]
[http://dx.doi.org/10.1016/j.cbpa.2005.10.005] [PMID: 16233988]
[http://dx.doi.org/10.1002/anie.200600033] [PMID: 16544355]
[http://dx.doi.org/10.1021/nl100996u] [PMID: 20684528]
[http://dx.doi.org/10.1016/j.msec.2011.04.010]
[http://dx.doi.org/10.1039/c1jm10749f]
[http://dx.doi.org/10.1021/jp806751k]
[http://dx.doi.org/10.1002/chem.201103445] [PMID: 22374621]
[http://dx.doi.org/10.1016/j.carbon.2012.02.083]
[http://dx.doi.org/10.1002/smll.201101613] [PMID: 22228696]
[http://dx.doi.org/10.1021/mp2005356] [PMID: 22264154]
[http://dx.doi.org/10.1007/s12274-012-0200-y]
[http://dx.doi.org/10.1039/b821416f]
[http://dx.doi.org/10.1021/tx400385x] [PMID: 24422439]
[http://dx.doi.org/10.1021/cm301939s]
[http://dx.doi.org/10.1016/j.taap.2004.06.021] [PMID: 15629195]
[http://dx.doi.org/10.1038/35041687] [PMID: 11089981]
[http://dx.doi.org/10.1021/cm062691p]
[http://dx.doi.org/10.1093/toxsci/kfy235] [PMID: 30239936]
[http://dx.doi.org/10.1016/j.carbon.2009.01.028]