Cationic Peptides: Distribution and Mechanisms of Resistance

Title: Cationic Peptides: Distribution and Mechanisms of Resistance

Volume: 8 Issue: 9

Author(s): Deirdre A. Devine and Robert E.W. Hancock

Affiliation:

Keywords: Cationic Peptides, Cationic antimicrobial peptides, antimicrobial peptides, cationic abtimicrobial peptides, phopq, phopphoq regulon, burkholderia cepacia, proteases

Abstract: Cationic antimicrobial peptides are observed throughout nature. In mammals they are observed both at epithelial surfaces and within the granules of phagocytic cells. They are an important component of innate defences, since in addition to their ability to kill microorganisms, they are able to modulate inflammatory responses. With respect to their ability to kill bacteria, it is very difficult to isolate resistant mutants. However there are a few known mechanisms of intrinsic resistance, including PhoPQ-dependent and other alterations in lipopolysaccharide structure that influence self promoted uptake, and protease-mediated resistance.

Cite this article as:

Devine A. Deirdre and Hancock E.W. Robert, Cationic Peptides: Distribution and Mechanisms of Resistance, Current Pharmaceutical Design 2002; 8 (9) . https://dx.doi.org/10.2174/1381612023395501