Solution-Phase Parallel Synthesis of an Isoflavone Library for the Discovery of Novel Antigiardial Agents

Title: Solution-Phase Parallel Synthesis of an Isoflavone Library for the Discovery of Novel Antigiardial Agents

Volume: 5 Issue: 6

Author(s): T. Mineno, K.M. Stanford, L.A. Walker and M.A. Avery

Affiliation:

Abstract: Combinatorial chemistry has become a dramatically useful tool for the development of new medicinal agents. In the search to discover a novel and effective lead for the treatment of giardiasis, solutionphase synthesis of a library of isoflavone derivatives has been accomplished. Of the products screened, several compounds such as P(A1,B1) and P(A1,B11) exhibited potent antigiardial activity. The details of synthesis, in vitro antigiardial assay, and preliminary structure-activity relationships of these compounds are described.

Cite this article as:

T. Mineno , K.M. Stanford , L.A. Walker and M.A. Avery , Solution-Phase Parallel Synthesis of an Isoflavone Library for the Discovery of Novel Antigiardial Agents, Combinatorial Chemistry & High Throughput Screening 2002; 5 (6) . https://dx.doi.org/10.2174/1386207023330138