Chemistry and Biological Activity of [1,2,3]-Benzotriazine Derivatives

Title:Chemistry and Biological Activity of [1,2,3]-Benzotriazine Derivatives

Volume: 22 Issue: 28

Author(s): Ghodsi Mohammadi Ziarani*, Manizheh Mostofi and Negar Lashgari

Affiliation:

• Department of Chemistry, Alzahra University, Tehran, P.O. Box 1993893973,Iran

Keywords: [1, 2, 3]- Benzotriazines, [1, 2, 3]- BenzotriazineN-oxide, [1, 2, 3]- Benzotriazin-4(3H)-one, 4- Hydroxy- [1, 2, 3]-benzotriazines, coupling agent, HOOBt.

Abstract: [1,2,3]-Benzotriazines represent an interesting category of heterocyclic compounds. Various synthetic methods, key reactions and biological aspects have been highlighted. In particular, some analogues have shown antitumor activity. [1,2,3]- Benzotriazin-4-one derivatives are applied extensively as herbicides, insecticides and nematicides. Incorporation of these compounds into the human food chain is a cause of concern, since their toxicity to man is well documented. This review is an attempt to discuss synthesis, chemical reactions, applications and pharmacological aspects of [1,2,3]- benzotriazine analogues from 1957 till date.

Cite this article as:

Ziarani Mohammadi Ghodsi *, Mostofi Manizheh and Lashgari Negar , Chemistry and Biological Activity of [1,2,3]-Benzotriazine Derivatives, Current Organic Chemistry 2018; 22 (28) . https://dx.doi.org/10.2174/1385272822666181109123711