Diversity of Anticancer and Antimicrobial Compounds from Lichens and Lichen-derived Fungi: A Systematic Review (1985-2017)

Title:Diversity of Anticancer and Antimicrobial Compounds from Lichens and Lichen-derived Fungi: A Systematic Review (1985-2017)

Volume: 22 Issue: 25

Author(s): Buddha Bahadur Basnet, Hongwei Liu*, Li Liu and Yerlan Melsuly Suleimen

Affiliation:

• State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing,China

Keywords: Lichen, anticancer and antimicrobial, biodiversity, diverse metabolites, secondary metabolites, lichenized fungi.

Abstract: The emergence of multidrug-resistant (MDR) pathogens and cancers alarms the world for the urgent exploration of new therapeutic drugs to treat the superbugs and cancer patients. Since the ancient time, natural products and/or their derivatives have become continuous sources of leading commercialized pharmacological compounds that are used as antibiotics and antitumor agents. An unexplored source of natural products, lichen, currently has evolved into a propitious source of diverse secondary metabolites with various bio-activities including anticancer and antimicrobial, offering the abundant potentiality for future drugs. Herein, we summarized the progress in the discovery of structurally diverse anticancer compounds (C1-C85) with their plausible mode of action and antimicrobial compounds (M1-M112) from lichen and lichen-derived fungi together with their biodiversity. This review covers natural products discussed in literature from January 1985 to December 2017.

Cite this article as:

Basnet Bahadur Buddha , Liu Hongwei *, Liu Li and Suleimen Melsuly Yerlan , Diversity of Anticancer and Antimicrobial Compounds from Lichens and Lichen-derived Fungi: A Systematic Review (1985-2017), Current Organic Chemistry 2018; 22 (25) . https://dx.doi.org/10.2174/1385272822666181109110813