Alkylaminopropenones and Alkylamino-Propenoates as Efficient and Versatile Synthons in Microwave-Assisted Combinatorial Synthesis

Title: Alkylaminopropenones and Alkylamino-Propenoates as Efficient and Versatile Synthons in Microwave-Assisted Combinatorial Synthesis

Volume: 5 Issue: 7

Author(s): J. Westman, R. Lundin, J. Stalberg, M. Ostbye, A. Franzen and A. Hurynowicz

Affiliation:

Abstract: A simple and fast one-pot method using microwave irradiation for the synthesis of a number of small libraries of diverse heterocycles is described in this paper. The two-step one-pot method includes the formation of alkylaminopropenones or alkylaminopropenoates in 5 min at 180°C and a subsequent treatment with dinucleophiles for 3 to 5 min at 150°C to 180°C to form a variety of biologically interesting heterocycles in a cascade-type reaction. The combination of combinatorial chemistry and microwave-assisted synthesis was found to be very efficient.

Cite this article as:

J. Westman , R. Lundin , J. Stalberg , M. Ostbye , A. Franzen and A. Hurynowicz , Alkylaminopropenones and Alkylamino-Propenoates as Efficient and Versatile Synthons in Microwave-Assisted Combinatorial Synthesis, Combinatorial Chemistry & High Throughput Screening 2002; 5 (7) . https://dx.doi.org/10.2174/1386207023330048