摘要
1984年发现热休克因子1（HSF1）是热休克反应的主要调节因子。 在这种经典作用中，HSF1在细胞应激如热休克后被激活，最终导致HSF1介导的热休克蛋白表达以保护蛋白质组并在这些急性应激中存活。 然而，现在越来越清楚的是，HSF1在几种疾病中也起着重要作用，可能没有比癌症更突出。 HSF1似乎通过支持恶性肿瘤的多个方面（包括迁移，侵袭，增殖和癌细胞代谢等）在癌症中具有多效性。 由于HSF1的这些功能和其他功能，它已被研究作为多种癌症类型的患者结果的生物标志物。 单独的HSF1表达可预测多种癌症类型中的患者结果，但在其他情况下，HSF1活性的标志物更具预测性。 显然，需要进一步的工作来梳理出哪些标志物最能代表HSF1的肿瘤促进作用。 另外，已经有几种尝试开发小分子抑制剂以降低HSF1活性。 所有这些HSF1抑制剂仍处于临床前模型中，但在抑制肿瘤生长方面表现出不同水平的功效。 在过去十年中，HSF1在癌症中的相关研究的增长是巨大的，在此过程中发现了HSF1的许多新功能。 为了使这些发现达到临床影响，需要继续进一步开发HSF1作为生物标志物或治疗靶标。
关键词: HSF1，转移，生物标志物，治疗，EMT，入侵，迁移。
图形摘要
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