Small Molecule Activators of the Insulin Receptor: Potential New Therapeutic Agents for the Treatment of Diabetes Mellitus

Title: Small Molecule Activators of the Insulin Receptor: Potential New Therapeutic Agents for the Treatment of Diabetes Mellitus

Volume: 9 Issue: 24

Author(s): Edgardo Laborde and Prasad Manchem

Affiliation:

Keywords: diabetes mellitus, glucose homeostasis, insulin receptor, insulin signaling, insulin resistance, insulin-receptor activation, insulin mimetic, small molecule insulin-receptor activator

Abstract: Diabetes mellitus refers to a spectrum of syndromes characterized by abnormally high levels of glucose in blood. These syndromes are associated with an absolute (Type 1 diabetes) or relative (Type 2 diabetes) deficiency of insulin, coupled with varying degrees of peripheral resistance to the actions of insulin. Clinical studies have shown that controlling hyperglycemia significantly reduces the appearance and progression of the vascular complications associated with diabetes.

Cite this article as:

Laborde Edgardo and Manchem Prasad, Small Molecule Activators of the Insulin Receptor: Potential New Therapeutic Agents for the Treatment of Diabetes Mellitus, Current Medicinal Chemistry 2002; 9 (24) . https://dx.doi.org/10.2174/0929867023368665