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Current Nanomedicine

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ISSN (Print): 2468-1873
ISSN (Online): 2468-1881

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Research Article

Influence of Lipid’s Main Transition Temperature on the Stability of Chimeric Liposomal Systems

Author(s): Konstantina Zouliati, Christina Massala, Natassa Pippa, Nikolaos Naziris, Stergios Pispas and Costas Demetzos*

Volume 9, Issue 2, 2019

Page: [158 - 165] Pages: 8

DOI: 10.2174/2405461503666180912095425

Price: $65

Abstract

Background: The incorporation of polymeric components into liposomes promotes structural rearrangement of the lipid bilayers that could affect their properties and their behavior. Therefore, by mixing phospholipids with polymeric compounds the, socalled chimeric liposomal nanosystems are produced and could be advantageous, compared with conventional (e.g. composed of pure phospholipids) liposomal nanostructures.

Objective: In this work, we used lipids with different main transition temperature (Tm) i.e 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC, Tm=55°C), L-α-phosphatidylcholine, hydrogenated (Soy) (HSPC, Tm=52 °C) and egg phosphatidylcholine (EggPC, Tm=23 °C) and we studied and compared the physicochemical characteristics and the stability of conventional with that of chimeric liposomes.

Methods: Thin-film hydration method (TFH) was used as the preparation protocol for all systems. Dynamic and electrophoretic light scattering (DLS and ELS) were utilized in order to elucidate the physicochemical characteristics of all systems. All liposomal systems exhibited sizes below 100nm while the ζ-potential was around zero, indicating the absence of surface charge.

Results: The results revealed that the Tm of each phospholipid influences the biophysical behavior of the lipidic membrane, which contributes to the physicochemical characteristics and affects the physical stability of the liposomal nanosystems. The nature and physicochemical properties of each phospholipid seem to play a key role, regarding the structural characteristics and the formation process of the liposomal nanosystems.

Conclusion: Comparing the physicochemical properties of the conventional liposomes with those of the chimeric liposomal systems, we conclude that the complexity of the latter, due to the incorporation of the polymeric guest into the lipidic bilayer, revealed new properties, which correspond to increased physical stability.

Keywords: Chimeric liposomes, phospholipids, block copolymer, main transition, physicochemical properties, colloidal stability.

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[1]
Devalappy H, Chakilam A, Amiji MM. Role of nanotechnology in pharmaceutical product development. J Pharm Sci 2007; 96: 2547-65.
[2]
Onoue S, Yamada S, Chan HK. Nanodrugs: pharmacokinetics and safety. Int J Nanomedicine 2014; 9: 1025-37.
[3]
Narang AS, Chang RK, Hussain MA. Pharmaceutical development and regulatory considerations for nanoparticles and nanoparticulate drug delivery systems. J Pharm Sci 2013; 102: 3867-82.
[4]
Allen TM, Cullis PR. Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev 2013; 65: 36-48.
[5]
Bulbake U, Doppalapudi S, Kommineri N, Khan W. Liposomal formulations in clinical use: An updated review. Pharmaceutics 2017; 9: E12.
[6]
Cattel L, Ceruti M, Dosio F. From conventional to stealth liposomes: a new Frontier in cancer chemotherapy. J Chemother 2004; 16: 94-7.
[7]
Mufamadi MS, Pillay V, Choonara YE, et al. A review on composite liposomal technologies for specialized drug delivery. J Drug Deliv 2011; 939851: 19.
[8]
Naziris N, Pippa N, Pispas S, Demetzos C. Stimuli-responsive Drug Delivery Nanosystems: From Bench to Clinic. Curr Nanomed 2016; 6: 1-20.
[9]
Pispas S, Sarantopoulou E. Self-assembly in mixed aqueous solutions of amphiphilic block copolymers and vesicle-forming surfactant. Langmuir 2007; 23: 7484-90.
[10]
Pispas S. Self-assembled nanostructures in mixed anionic-neutral double hydrophilic block copolymer/cationic vesicle -forming surfactant solutions. Soft Matter 2011; 7: 474-82.
[11]
Pispas S. Vesicular structures in mixed block copolymer/surfactant solutions. Soft Matter 2011; 7: 8697-701.
[12]
Demetzos C, Pippa N. Advanced drug delivery nanosystems (aDDnSs): a mini-review. Drug Deliv 2014; 21: 250-7.
[13]
Pippa N, Pispas S, Demetzos C. The fractal hologram and elucidation of the structure of liposomal carriers in aqueous and biological media. Int J Pharm 2012; 430: 65-73.
[14]
Pippa N, Pispas S, Demetzos C. The delineation of the morphology of charged liposomal vectors via a fractal analysis in aqueous and biological media: physicochemical and self-assembly studies. Int J Pharm 2012; 437: 264-74.
[15]
Pippa N, Kaditi E, Pispas S, Demetzos C. PEO-b-PCL: DPPC chimeric nanocarriers: self-assembly aspects in aqueous and biological media and drug incorporation. Soft Matter 2013; 9: 4073-82.
[16]
Pippa N, Merkouraki M, Pispas S, Demetzos C. DPPC:MPOx chimeric advanced drug delivery nanosystems (chi-aDDnSs): physicochemical and structural characterization, stability and drug release studies. Int J Pharm 2013; 450: 1-10.
[17]
Chibowski E, Szcześ A. Zeta potential and surface charge of DPPC and DOPC liposomes in the presence of PLC enzyme. Adsorption 2016; 22: 755-65.
[18]
Pippa N, Psarommati F, Demetzos C. The Shape/Morphology Balance: A Study of Stealth Liposomes via Fractal Analysis and Drug Encapsulation. Pharm Res 2013; 30: 2385-95.
[19]
Worthen AJ, Tran V, Cornell KA, Truskett TM, Johnston KP. Steric stabilization of nanoparticles with grafted low molecular weight ligands in highly concentrated brines including divalent ions. Soft Matter 2016; 7: 2025-39.

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