Mechanisms and Treatments of Oxidative Stress in Atrial Fibrillation

Title:Mechanisms and Treatments of Oxidative Stress in Atrial Fibrillation

Volume: 24 Issue: 26

Author(s): Xiaomeng Ren, Xiaofeng Wang, Mengchen Yuan, Chao Tian, Huilong Li, Xinyu Yang, Xinye Li, Yanda Li, Yihan Yang, Nian Liu, Hongcai Shang, Yonghong Gao*Yanwei Xing*

Affiliation:

• Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700,China

• Guang'an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053,China

Keywords: Oxidative stress, atrial fibrillation, mechanisms, treatments, ROS, angiotensin.

Abstract: Atrial fibrillation (AF) is a frequent cardiac arrhythmia. It is a common major cause of serious diseases and is an increasing health-care burden. AF is associated with an excess amount of reactive oxygen species. In this review, we summarize several possible reactive oxygen species pathways that induce AF based on atrial electrical and structural remodeling data. The sources and factors implicated in AF-related oxidative stress include NADPH oxidase activation, calcium overloading and mitochondrial damage, angiotensin system activation, nitric oxide synthase uncoupling, and xanthine oxidase activation-associated cardiovascular conditions. Scavenging oxidative stress markers and related substances are essential aspects of these molecular mechanisms, and may be a therapeutic target in AF.

Cite this article as:

Ren Xiaomeng , Wang Xiaofeng , Yuan Mengchen, Tian Chao , Li Huilong , Yang Xinyu , Li Xinye, Li Yanda , Yang Yihan, Liu Nian , Shang Hongcai , Gao Yonghong*, Xing Yanwei *, Mechanisms and Treatments of Oxidative Stress in Atrial Fibrillation, Current Pharmaceutical Design 2018; 24 (26) . https://dx.doi.org/10.2174/1381612824666180903144042