The Anticancer Effect of Sanguinarine: A Review

Title:The Anticancer Effect of Sanguinarine: A Review

Volume: 24 Issue: 24

Author(s): Chenxing Fu, Guiping Guan*Hongbing Wang*

Affiliation:

• College of Bioscience and Biotechnology, College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128,China

• Hunan Institute of Animal and Veterinary Science, Changsha, Changsha 410131,China

Keywords: Sanguinarine, anti-tumor, apoptosis, pathways, anti-inflammatory, cancer.

Abstract: In vitro and in vivo studies have revealed that Sanguinarine has antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory effects on tumor cells of a variety of cancers. Previous research showed that sanguinarine induced apoptosis (cell death) and/or antiproliferative while reducing tumor cell antiangiogenic and anti-invasive properties. This paper describes various sanguinarine anti-cancer mechanisms, including inhibition of erroneously-activated signal transduction pathways, apoptosis, and tumor cell proliferation inhibition.

Cite this article as:

Fu Chenxing , Guan Guiping *, Wang Hongbing *, The Anticancer Effect of Sanguinarine: A Review, Current Pharmaceutical Design 2018; 24 (24) . https://dx.doi.org/10.2174/1381612824666180829100601