Current Perspectives Regarding Stem Cell-based Therapy for Ischemic Stroke

Title:Current Perspectives Regarding Stem Cell-based Therapy for Ischemic Stroke

Volume: 24 Issue: 28

Author(s): Kyeong-Ah Kwak, Ho-Beom Kwon, Joo Won Lee and Young-Seok Park*

Affiliation:

• Department of Oral Anatomy, Seoul National University School of Dentistry and Dental Research Institute, Seoul, 101 Daehakro, Jongno-Gu, Seoul, 03080,Korea

Keywords: Stroke, cell-based therapy, clinical trials, stem cells, angiogenesis, immunomodulation.

Abstract: Stroke is a leading cause of death and disability worldwide. Conventional treatment has a limitation of very narrow therapeutic time window and its devastating nature necessitate a novel regenerative approach. Transplanted stem cells resulted in functional recovery through multiple mechanisms including neuroprotection, neurogenesis, angiogenesis, immunomodulation, and anti-inflammatory effects. Despite the promising features shown in experimental studies, results from clinical trials are inconclusive from the perspective of efficacy. The present review presents a synopsis of stem cell research on ischemic stroke treatment according to cell type. Clinical trials to the present are briefly summarized. Finally, the hurdles and issues to be solved are discussed for clinical application.

Cite this article as:

Kwak Kyeong-Ah , Kwon Ho-Beom , Lee Won Joo and Park Young-Seok*, Current Perspectives Regarding Stem Cell-based Therapy for Ischemic Stroke, Current Pharmaceutical Design 2018; 24 (28) . https://dx.doi.org/10.2174/1381612824666180604111806