Kinetics of the Solution-Mediated Polymorphic Transformation of Organic Compounds

Title:Kinetics of the Solution-Mediated Polymorphic Transformation of Organic Compounds

Volume: 24 Issue: 21

Author(s): Lek Wantha*

Affiliation:

• Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Long-Hard Bangsaen Road, Muang District, Chonburi 20131,Thailand

Keywords: Polymorphism, organic compound, crystallization from solution, kinetics, solution-mediated polymorphic transformation, process modelling.

Abstract: Polymorphism is a behavior of a substance to crystallize into more than one district crystal structures. Preferential formation of a polymorph depends strongly on the kinetics of the relevant mechanisms. Solutionmediated polymorphic transformation is an important mechanism in crystallization of organic compounds from solution. Knowing its kinetics allows us to understand the process and control the polymorphic formation. In this review, concepts, kinetics, and process modeling of crystallization and solution-mediated polymorphic transformation are examined and summarized.

Cite this article as:

Wantha Lek *, Kinetics of the Solution-Mediated Polymorphic Transformation of Organic Compounds, Current Pharmaceutical Design 2018; 24 (21) . https://dx.doi.org/10.2174/1381612824666180601093228