The Several Activities of 4 - Methyl Pyrazole in Animals and Humans

Title:The Several Activities of 4 - Methyl Pyrazole in Animals and Humans

Volume: 24 Issue: 18

Author(s): Gaetano Iaquinto*

Affiliation:

• Gastroenterology and Digestive Endoscopy Service, S. Rita Clinic, via Appia, 83042, Atripalda,Italy

Keywords: 4 methyl pyrazole, alchol gastric, mucosal injury, gastroprotection, ADH, ethanol, alcohol.

Abstract: 4-MP is a potent competitive inhibitor of ADH activity with an affinity about a 1000 times more than toxic alcohols. 4-MP was shown to reduce the formation of toxic metabolites in lethal methanol and ethylene glycol poisoning in animal models and in methanol poisoning in humans. 4-MP has long-lasting gastroprotective effect against ethanol and other chemically induced acute gastric mucosa lesions in rats. We showed, for the first time, that 4-MP also provides significant protection of the human stomach against alcohol induced acute mucosal injury.

Cite this article as:

Iaquinto Gaetano *, The Several Activities of 4 - Methyl Pyrazole in Animals and Humans, Current Pharmaceutical Design 2018; 24 (18) . https://dx.doi.org/10.2174/1381612824666180529081328