The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods

Title: The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods

Volume: 5 Issue: 3

Author(s): M. G. Organ, C. E. Dixon, D. Mayhew, D. J. Parks and E. A. Arvanitis

Affiliation:

Keywords: molecular library, solution phase method, ptbd resin, scx

Abstract: The preparation of molecular libraries of aminomethylbiaryls, allylic amines, and ethanolamines using solution-phase methodology is described. In particular, the use of a solid-supported base reagent (PTBD resin) and strong cation exchange(SCX) resin to effect ‘catch and release’ purification across these diverse libraries is highlighted.

Cite this article as:

Organ G. M., Dixon E. C., Mayhew D., Parks J. D. and Arvanitis A. E., The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods, Combinatorial Chemistry & High Throughput Screening 2002; 5 (3) . https://dx.doi.org/10.2174/1386207024607301