Synthesis of Trifluoromethyl Ketones Using Polymer-Supported Reagents

I.   R.   Baxendale; S.   V.   Ley; W.      Lumeras; M.      Nesi

doi:10.2174/1386207024607220

Abstract

A two step synthesis of trifluoromethyl ketones from aldehydes is reported. A combination of polymer-supported reagents and sequestering agents were employed to effect the transformation without the need for chromatographic purification.

Keywords: polymer-supported reagent, sequestering agent, multi-parallel synthesis

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Combinatorial Chemistry & High Throughput Screening

Title: Synthesis of Trifluoromethyl Ketones Using Polymer-Supported Reagents

Volume: 5 Issue: 3

Author(s): I. R. Baxendale, S. V. Ley, W. Lumeras and M. Nesi

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Keywords: polymer-supported reagent, sequestering agent, multi-parallel synthesis

Abstract: A two step synthesis of trifluoromethyl ketones from aldehydes is reported. A combination of polymer-supported reagents and sequestering agents were employed to effect the transformation without the need for chromatographic purification.

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Baxendale R. I., Ley V. S., Lumeras W. and Nesi M., Synthesis of Trifluoromethyl Ketones Using Polymer-Supported Reagents, Combinatorial Chemistry & High Throughput Screening 2002; 5 (3) . https://dx.doi.org/10.2174/1386207024607220