Recent Advances in Magnetic Nanoparticle-based Molecular Probes for Hepatocellular Carcinoma Diagnosis and Therapy

Title:Recent Advances in Magnetic Nanoparticle-based Molecular Probes for Hepatocellular Carcinoma Diagnosis and Therapy

Volume: 24 Issue: 21

Author(s): Qi Zhang, Sudan Wang, Ruirui Qiao*, Michael R. Whittaker, John F. Quinn, Thomas P. Davis and Hongjun Li*

Affiliation:

• ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052,Australia

• Department of Radiology, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, You An Men Wai, Feng Tai District, Beijing 100069,China

Keywords: Magnetic nanoparticle, MRI, hepatocellular carcinoma, molecular imaging, cancer, diagnosis.

Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, leading to the second most likely cause of cancer-related deaths. Medical imaging is crucial in clinic for HCC screening and diagnosis. Due to the relatively high special resolution and excellent sensitivity, magnetic resonance imaging (MRI) by using magnetic nanoparticle-based contrast agents has been used so far in HCC imaging and staging, demonstrating great potential and promising in vivo applications. This review focuses on the use of different magnetic nanoparticles for construction of HCC nanoprobes for MR imaging and theranostic purpose.

Cite this article as:

Zhang Qi , Wang Sudan , Qiao Ruirui *, Whittaker R. Michael , Quinn F. John , Davis P. Thomas and Li Hongjun *, Recent Advances in Magnetic Nanoparticle-based Molecular Probes for Hepatocellular Carcinoma Diagnosis and Therapy, Current Pharmaceutical Design 2018; 24 (21) . https://dx.doi.org/10.2174/1381612824666180516111939