Insights into Anti-Trypanosomal Agents Based on Synthetic Glycoconjugates

Title:Insights into Anti-Trypanosomal Agents Based on Synthetic Glycoconjugates

Volume: 18 Issue: 5

Author(s): Vanessa Leiria Campo*, Marcelo Fiori Marchiori and Ivone Carvalho

Affiliation:

• Faculty of Pharmaceutical Sciences of Ribeirao Preto - USP. Av. do Cafe S/N, CEP 14040-903, Ribeirao Preto - SP,Brazil

Keywords: Chagas disease, Trypanosoma cruzi, Glycoconjugates, Anti-trypanosomal agents, trans-Sialidase, Vaccines.

Abstract: Chagas disease is still a worldwide threat, with estimated 6 to 7 million infected people, mainly in Latin America. Current treatments still rely only on benznidazol and nifurtimox, drugs with poor efficacy in chronic infection phase and recognized toxicity. Thus, there is an urgent need for new therapeutic agents against this disease. In this review we present an updated selection over the last decade of synthetic glycoconjugates as anti-trypanosomal agents, properly addressed as monosaccharideand disaccharide-based agents, and multivalent-based derivatives, disclosing relevant methods for their synthesis, along with their activities on T. cruzi and its trans-sialidase (TcTS). In addition, synthetic glycoconjugates as potential vaccines and diagnostic antigens against T. cruzi are also reported.

Cite this article as:

Campo Leiria Vanessa*, Marchiori Fiori Marcelo and Carvalho Ivone , Insights into Anti-Trypanosomal Agents Based on Synthetic Glycoconjugates, Current Topics in Medicinal Chemistry 2018; 18 (5) . https://dx.doi.org/10.2174/1568026618666180509145305