Neurotransmission and Neurotoxicity by Nitric Oxide, Catecholamines, and Glutamate: Unifying Themes of Reactive Oxygen Species and Electron Transfer

Title: Neurotransmission and Neurotoxicity by Nitric Oxide, Catecholamines, and Glutamate: Unifying Themes of Reactive Oxygen Species and Electron Transfer

Volume: 10 Issue: 24

Author(s): Jason D. Jacintho and Peter Kovacic

Affiliation:

Keywords: nitric oxide, catecholamines, glutamate, neurotransmission, neurotoxicity, oxidative stress, reactive oxygen species

Abstract: This review treats the mechanism of nitric oxide, catecholamines, and glutamate as important neurotransmitters and as neurotoxins, based on involvement of reactive oxygen species (ROS) and electron transfer (ET). ROS and ET can serve as a unifying framework for both transmission and toxicity, with ROS concentration being a crucial issue. Cell signaling, electrochemistry, antioxidants, and apoptosis are also discussed.

Cite this article as:

Jacintho D. Jason and Kovacic Peter, Neurotransmission and Neurotoxicity by Nitric Oxide, Catecholamines, and Glutamate: Unifying Themes of Reactive Oxygen Species and Electron Transfer, Current Medicinal Chemistry 2003; 10 (24) . https://dx.doi.org/10.2174/0929867033456404