Chemical Genomics-Based Target Identification and Validation of Anti- Angiogenic Agents

Ho   Jeong   Kwon

doi:10.2174/0929867033457755

Abstract

The recent use of chemical genomics to identify bioactive small molecules that interact with specific proteins has had a tremendous impact on both the functional analysis of genes and drug development. Accordingly, the current review focuses on the utilization of this new research engine in the target identification and validation of antiangiogenic agents capable of regulating the growth and spread of cancer cells. In addition, the use of chemical genomics to discover novel anti-angiogenic agent targets and to validate their biological relevancy is providing new insights into the biological role of targets in angiogenesis as well as advancing the development of new antiangiogenic agents.

Keywords: chemical genomics, angiogenesis, anti-angiogenic agents, target identification and validation, methionine aminopeptidase II, hsp90, histone deacetylase