Phage-based Nanomedicines as New Immune Therapeutic Agents for Breast Cancer

Title:Phage-based Nanomedicines as New Immune Therapeutic Agents for Breast Cancer

Volume: 24 Issue: 11

Author(s): Atefeh Arab, Rezvan Yazdian Robati, Jessica Nicastro, Roderick Slavcev and Javad Behravan*

Affiliation:

• School of Pharmacy, University of Waterloo, 200 University Ave, Waterloo,Canada

Keywords: Bacteriophage, phage display, breast cancer, immune therapeutics, peptide library, vaccine.

Abstract: Despite years of investigation, breast cancer remains a major cause of death worldwide. Phage display is a powerful molecular method in which peptide and protein libraries can be displayed via genetic fusions on the surface of phages. This approach has tremendous potential for biomedical applications and has already facilitated the discovery of specific antibodies, specific antigens, and peptides with potential roles in the diagnosis and treatment of malignancies including breast cancer. In this review, we discuss the new and the latest advancements in the applications of the phage display technique in the provision of immune therapeutics for breast cancer.

Cite this article as:

Arab Atefeh , Robati Yazdian Rezvan, Nicastro Jessica, Slavcev Roderick and Behravan Javad *, Phage-based Nanomedicines as New Immune Therapeutic Agents for Breast Cancer, Current Pharmaceutical Design 2018; 24 (11) . https://dx.doi.org/10.2174/1381612824666180327152117